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We evaluated hyperfiltration in SCD patients and its \u201cnormalization.\u201d Routine visit data were collected retrospectively from adult SCD patients in a single centre from 2004 to 2013. Baseline was defined as first available serum creatinine and hyperfiltration as estimated glomerular filtration rates (eGFR) &gt;130\u00a0ml\/min\/1\u00b773\u00a0m<jats:sup>2<\/jats:sup> for women and &gt;140\u00a0ml\/min\/1\u00b773\u00a0m<jats:sup>2<\/jats:sup> for men. Normalization of hyperfiltration was eGFR reduction to 90\u2013130\u00a0ml\/min\/1\u00b773\u00a0m<jats:sup>2<\/jats:sup> for women or 90\u2013140\u00a0ml\/min\/1\u00b773\u00a0m<jats:sup>2<\/jats:sup> for men. Among 292 patients, median age was 27 years [interquartile range (IQR):20\u00b70\u201338\u00b70], and 56\u00b78% had baseline hyperfiltration. Baseline hyperfiltration was inversely associated with age [odds ratio (OR):0\u00b786, 95% confidence interval (CI): 0\u00b782\u20130\u00b790; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001], male sex (OR:0\u00b716, 95% CI: 0\u00b707\u20130\u00b741; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001), haemoglobin (OR:0\u00b776, 95% CI 0\u00b761\u20130\u00b794; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701), weight (OR:0\u00b796, 95% CI: 0\u00b793\u20130\u00b799; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004), and angiotensin\u2010converting enzyme inhibitor\/angiotensin receptor blocker (ACE\u2010I\/ARB) use (OR:0\u00b708, 95% CI: 0\u00b701\u20130\u00b775; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703), and positively with hydroxycarbamide use (OR:2\u00b799, 95% CI: 1\u00b718\u20137\u00b756; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702). Of 89 hyperfiltration patients without baseline proteinuria, 10 (11\u00b72%) developed new\u2010onset proteinuria [median 1\u00b705\u00a0years (IQR:0\u00b763\u20132\u00b709)]. Normalization of hyperfiltration was less likely with higher baseline eGFR [hazard ratio (HR):0\u00b790, 95% CI: 0\u00b786\u20130\u00b795; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001] and more likely in males (HR:6\u00b735, 95% CI:2\u00b771\u201314\u00b786, &lt;0\u00b70001). Hyperfiltration is common in adult SCD patients, particularly when younger. Decline to normal values is more likely in males, possibly representing kidney function loss rather than improvement in hyperfiltration.<\/jats:p>","DOI":"10.1111\/bjh.17723","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T01:54:10Z","timestamp":1629165250000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Longitudinal study of glomerular hyperfiltration and normalization of estimated glomerular filtration in adults with sickle cell disease"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-7497","authenticated-orcid":false,"given":"Vimal K.","family":"Derebail","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension UNC Kidney Center University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingning","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of North Carolina at Charlotte Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-9982","authenticated-orcid":false,"given":"Kenneth I.","family":"Ataga","sequence":"additional","affiliation":[{"name":"Center for Sickle Cell Disease University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23762"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200004)63:4<205::AID-AJH8>3.0.CO;2-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016060666"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03080314"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25390"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08511109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23817"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162652"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016070711"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001378"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.12.027"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.08.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.09.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60355-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1857-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01600211"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(55)90239-4"},{"issue":"2","key":"e_1_2_8_20_1","first-page":"185","article-title":"Renal function studies in pediatrics. 1. 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