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Therefore, a phase 2 study of fimepinostat was conducted in this patient population with 66 eligible patients treated. The primary end\u2010point of overall response (OR) rate for patients with MYC\u2010IHC \u226540% (<jats:italic>n<\/jats:italic>\u00a0=\u00a046) was 15%. Subsequently, exploratory pooled analyses were performed including patients treated on both the phase 1 and 2 studies based upon the presence of MYC\u2010altered disease as well as a biomarker identified by Virtual Inference of Protein activity by Enriched Regulon analysis (VIPER). For these patients with MYC\u2010altered disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a063), the overall response (OR) rate was 22% with seven responding patients remaining on treatment for approximately two years or longer, and VIPER yielded a three\u2010protein biomarker classification with positive and negative predictive values of \u226585%. Prolonged durations of response were achieved by patients with MYC\u2010altered R\/R DLBCL\/HGBL treated with single\u2010agent fimepinostat. Combination therapies and\/or biomarker\u2010based patient selection strategies may lead to higher response rates in future clinical trials.<\/jats:p>","DOI":"10.1111\/bjh.17730","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T04:24:43Z","timestamp":1627964683000},"page":"201-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Fimepinostat (CUDC\u2010907) in patients with relapsed\/refractory diffuse large B cell and high\u2010grade B\u2010cell lymphoma: report of a phase 2 trial and exploratory biomarker analyses"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5077-4181","authenticated-orcid":false,"given":"Daniel J.","family":"Landsburg","sequence":"first","affiliation":[{"name":"University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan 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