{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:47:37Z","timestamp":1789523257311,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fetal neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies directed against the human platelet antigens (mostly HPA\u20101a or HPA\u20105b) of the (unborn) child and can lead to severe bleeding. Anti\u2010HPA\u20101a\u2010mediated FNAIT shows a severe clinical outcome more often than anti\u2010HPA\u20105b\u2010mediated FNAIT. Given the relatively high prevalence of anti\u2010HPA\u20105b in pregnant women, the detection of anti\u2010HPA\u20105b in FNAIT\u2010suspected cases may in some cases be an incidental finding. Therefore we investigated the frequency of anti\u2010HPA\u20105b\u2010associated severe bleeding in FNAIT. We performed a retrospective nationwide cohort study in cases with clinical suspicion of FNAIT. HPA antibody screening was performed using monoclonal antibody\u2010specific immobilisation of platelet antigens. Parents and neonates were typed for the cognate antigen. Clinical data were collected by a structured questionnaire. In 1\u2009864 suspected FNAIT cases, 161\u2009cases (8\u00b76%) had anti\u2010HPA\u20101a and 60 (3\u00b72%) had anti\u2010HPA\u20105b. The proportion of cases with severe bleeding did not differ between the cases with anti\u2010HPA\u20101a (14\/129; 11%) and anti\u2010HPA\u20105b (4\/40; 10%). In multigravida pregnant women with a FNAIT\u2010suspected child, 100% (81\/81) of anti\u2010HPA\u20101a cases and 79% (38\/48) of anti\u2010HPA\u20105b cases were HPA\u2010incompatible, whereas 86% and 52% respectively were expected, based on the HPA allele distribution. We conclude that anti\u2010HPA\u20105b can be associated with severe neonatal bleeding symptoms. A prospective study is needed for true assessment of the natural history of anti\u2010HPA\u20105b mediated FNAIT.<\/jats:p>","DOI":"10.1111\/bjh.17731","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:30:39Z","timestamp":1629160239000},"page":"595-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical characteristics of human platelet antigen (HPA)\u20101a and HPA\u20105b alloimmunised pregnancies and the association between platelet HPA\u20105b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3653-3234","authenticated-orcid":false,"given":"Thijs W.","family":"de Vos","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Neonatology Leiden University Medical Centre Leiden the Netherlands"},{"name":"Centre for Clinical Transfusion Research Sanquin Research Leiden the Netherlands"},{"name":"Department of Obstetrics and Gynecology Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-0446","authenticated-orcid":false,"given":"Leendert","family":"Porcelijn","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Hofstede\u2010van Egmond","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatology Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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