{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:10:33Z","timestamp":1790111433541,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003514","name":"Kommunfullm\u00e4ktige, Stockholms Stad","doi-asserted-by":"publisher","award":["543204"],"award-info":[{"award-number":["543204"]}],"id":[{"id":"10.13039\/501100003514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2017\/513"],"award-info":[{"award-number":["CAN 2017\/513"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Statin use has been associated with reduced mortality from several cancers but also suggested, <jats:italic>in\u00a0vitro,<\/jats:italic> to diminish the effectiveness of lymphoma treatments including rituximab. The present study aimed to assess the association of statin use with mortality in patients with non\u2010Hodgkin lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). We identified all incident NHLs and CLLs in Sweden from 2007 to 2013 with subtype information in the Swedish Lymphoma and Cancer Registers. Using Cox regression, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of pre\u2010 or post\u2010diagnosis statin use (yes\/no, intensity) with lymphoma\u2010specific, cardiovascular, or all\u2010cause mortality; and for follicular lymphoma (FL) by initial treatment strategy (active\/watch\u2010and\u2010wait). Among 16\u2009098 incident NHL\/CLL patients, 20% used statins at diagnosis. Pre\u2010 and post\u2010diagnosis statin use, and statin intensity were not consistently associated with any mortality outcome in patients with NHL, overall or for any subtype. For actively treated patients with FL, statin use did not appear to increase lymphoma\u2010specific mortality (vs. non\u2010users, HR [95% CI]<jats:sub>after diagnosis<\/jats:sub> 0\u00b787 [0\u00b745\u20131\u00b767]). For CLL, statin use was associated with all\u2010cause and cardiovascular but not consistently with lymphoma\u2010specific mortality. In conclusion, statin use was not associated with improved lymphoma survival but appears safe to use during lymphoma treatment.<\/jats:p>","DOI":"10.1111\/bjh.17733","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T11:30:24Z","timestamp":1627731024000},"page":"552-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Statin use and survival in 16\u2009098 patients with non\u2010Hodgkin lymphoma or chronic lymphocytic leukaemia treated in the rituximab era"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-2665","authenticated-orcid":false,"given":"Elsa","family":"Br\u00e5nvall","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden"},{"name":"Department of Medicine Division of Hematology Capio S:t G\u00f6rans Hospital Stockholm 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