{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:00:22Z","timestamp":1787763622154,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Adult T\u2010cell leukaemia\/lymphoma (ATL) patients have a poor prognosis. Here, we investigated the impact of <jats:italic>TP53<\/jats:italic> gene mutations on prognosis of ATL treated in different ways. Among 177 patients, we identified 47 single nucleotide variants or insertion\u2010deletions (SNVs\/indels) of the <jats:italic>TP53<\/jats:italic> gene in 37 individuals. <jats:italic>TP53<\/jats:italic> copy number variations (CNVs) were observed in 38 patients. Altogether, 67 of 177 patients harboured <jats:italic>TP53<\/jats:italic> SNVs\/indels or <jats:italic>TP53<\/jats:italic> CNVs, and were categorized as having <jats:italic>TP53<\/jats:italic> mutations. In the entire cohort, median survival of patients with and without <jats:italic>TP53<\/jats:italic> mutations was 1\u00b70 and 6\u00b77\u2009years respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090\u00b7001). After allogeneic haematopoietic stem cell transplantation (HSCT), median survival of patients with (<jats:italic>n<\/jats:italic>\u2009=\u200916) and without (<jats:italic>n<\/jats:italic>\u2009=\u200929) <jats:italic>TP53<\/jats:italic> mutations was 0\u00b74\u2009years and not reached respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7001). For patients receiving mogamulizumab without allogeneic HSCT, the median survival from the first dose of antibody in patients with <jats:italic>TP53<\/jats:italic> mutations (<jats:italic>n<\/jats:italic>\u2009=\u200927) was only 0\u00b79\u2009years, but 5\u00b71\u2009years in those without (<jats:italic>n<\/jats:italic>\u2009=\u200942; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090\u00b7001). Thus, <jats:italic>TP53<\/jats:italic> mutations are associated with unfavourable prognosis of ATL, regardless of treatment strategy. The establishment of alternative modalities to overcome the adverse impact of <jats:italic>TP53<\/jats:italic> mutations in patients with ATL is required.<\/jats:p>","DOI":"10.1111\/bjh.17749","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T04:02:00Z","timestamp":1629259320000},"page":"571-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinical significance of <i>TP53<\/i> mutations in adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-4862","authenticated-orcid":false,"given":"Yuma","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Graduate School of Medical Sciences Nagoya City University Nagoya 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