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While for patients with bone marrow failure the treatment follows that of immune\u2010mediated aplastic anaemia, that of classic, haemolytic PNH is based on anti\u2010complement medication. The anti\u2010C5 monoclonal antibody eculizumab has revolutionized treatment, resulting in control of intravascular haemolysis and thromboembolic risk, with improved long\u2010term survival. Novel strategies of complement inhibition are emerging. New anti\u2010C5 agents reproduce the safety and efficacy of eculizumab, with improved patient convenience. Proximal complement inhibitors have been developed to address C3\u2010mediated extra\u2010vascular haemolysis and seem to improve haematological response.<\/jats:p>","DOI":"10.1111\/bjh.17753","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T22:23:05Z","timestamp":1628202185000},"page":"288-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["How we(\u2019ll) treat paroxysmal nocturnal haemoglobinuria: diving into the future"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-5109","authenticated-orcid":false,"given":"Antonio Maria","family":"Risitano","sequence":"first","affiliation":[{"name":"Department of Onco\u2010Hematology AORN San Giuseppe Moscati Avellino  Avellino Italy"},{"name":"Department of Clinical Medicine and Surgery Federico II University of Naples  Naples Italy"},{"name":"Severe Aplastic Anaemia Working Party (SAAWP) of 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