{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:46:20Z","timestamp":1775853980532,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA6145\/3\u20101"],"award-info":[{"award-number":["HA6145\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We retrospectively investigated histopathological growth patterns in individuals with advanced nodular lymphocyte\u2010predominant Hodgkin lymphoma (NLPHL) treated within the randomized HD18 study. In all, 35\/60 patients (58%) presented with atypical growth patterns. Patients with atypical growth patterns more often had stage IV disease (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b70354) and splenic involvement (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b70048) than patients with typical growth patterns; a positive positron emission tomography after two cycles of chemotherapy (PET\u20102) tended to be more common (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b71078). Five\u2010year progression\u2010free survival [hazard ratio (HR)\u2009=\u20090\u00b786; 95% confidence interval (CI)\u2009=\u20090\u00b749\u20131\u00b747] and overall survival (HR\u2009=\u20090\u00b785; 95% CI\u2009=\u20090\u00b749\u20131\u00b751) did not differ between the groups after study treatment with PET\u20102\u2010guided escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). Thus, advanced NLPHL is often associated with atypical growth patterns but their prognostic impact is compensated by PET\u20102\u2010guided escalated BEACOPP.<\/jats:p>","DOI":"10.1111\/bjh.17770","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T02:04:33Z","timestamp":1629079473000},"page":"99-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Histopathological growth patterns in patients with advanced nodular lymphocyte\u2010predominant Hodgkin lymphoma treated within the randomized HD18 study: a report from the German Hodgkin Study Group"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-3514","authenticated-orcid":false,"given":"Dennis A.","family":"Eichenauer","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"B\u00fchnen","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Kreissl","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Goergen","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fuchs","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastian","family":"von Tresckow","sequence":"additional","affiliation":[{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"},{"name":"Department of Hematology and Stem Cell Transplantation West German Cancer Center University Hospital Essen University of Duisburg\u2010Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of W\u00fcrzburg and Comprehensive Cancer Center (CCC) Mainfranken W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Hematopathology Section\u00a0and Lymph Node Registry University Hospital Schleswig\u2010Holstein Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin\u2010Leo","family":"Hansmann","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz\u2010Wolfram","family":"Bernd","sequence":"additional","affiliation":[{"name":"Hematopathology L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred C.","family":"Feller","sequence":"additional","affiliation":[{"name":"Hematopathology L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Engert","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Borchmann","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-1091","authenticated-orcid":false,"given":"Sylvia","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt Frankfurt am Main 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