{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:52:46Z","timestamp":1774425166435,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771373"],"award-info":[{"award-number":["31771373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The expression of <jats:italic>GGCT<\/jats:italic> (\u03b3\u2010glutamyl cyclotransferase) is upregulated in various human cancers. \u03b3\u2010glutamyl cyclotransferase enzyme activity was originally purified from human red blood cells (RBCs), but the physiological function of <jats:italic>GGCT<\/jats:italic> in RBCs is still not clear. Here we reported that <jats:italic>Ggct<\/jats:italic> deletion in mice leads to splenomegaly and progressive anaemia phenotypes, due to elevated oxidative damage and the shortened life span of <jats:italic>Ggct<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> RBCs. <jats:italic>Ggct<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> RBCs have increased reactive oxygen species (ROS), and are more sensitive to H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced damage compared to control RBCs. Glutathione (GSH) and GSH synthesis precursor <jats:sc>l<\/jats:sc>\u2010cysteine are decreased in <jats:italic>Ggct<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> RBCs. Our study suggests a critical function of Ggct in RBC redox balance and life span maintenance through regulating GSH metabolism.<\/jats:p>","DOI":"10.1111\/bjh.17775","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:50:44Z","timestamp":1629334244000},"page":"267-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ggct (\u03b3\u2010glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival"],"prefix":"10.1111","volume":"195","author":[{"given":"Zaoke","family":"He","sequence":"first","affiliation":[{"name":"School of Life Science and Technology ShanghaiTech University Shanghai China"},{"name":"Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai China"},{"name":"University of Chinese Academy of Sciences Beijing 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