{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:29:55Z","timestamp":1791646195520,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The present study tested the impact of \u03b1\u2010thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no \u03b1\u2010thalassaemia (four \u03b1\u2010genes, <jats:italic>n<\/jats:italic>\u2009=\u200962), (ii) silent \u03b1\u2010thalassaemia (three \u03b1\u2010genes, <jats:italic>n<\/jats:italic>\u2009=\u200935) and (iii) homozygous \u03b1\u2010thalassaemia (two \u03b1\u2010genes, <jats:italic>n<\/jats:italic>\u2009=\u200912). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO<jats:sub>2<\/jats:sub>) was greater and the pO<jats:sub>2<\/jats:sub> at which RBC started to sickle was lower in the two \u03b1\u2010genes group compared to the other groups. Our present study showed an effect of \u03b1\u2010thalassaemia on oxygen gradient ektacytometry in SCA.<\/jats:p>","DOI":"10.1111\/bjh.17777","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T03:48:52Z","timestamp":1629085732000},"page":"629-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without \u03b1\u2010thalassaemia"],"prefix":"10.1111","volume":"195","author":[{"given":"Camille","family":"Boisson","sequence":"first","affiliation":[{"name":"Team \u2018Vascular Biology and Red Blood Cell\u2019 Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (LIBM) EA7424 Universit\u00e9 Claude Bernard Lyon 1 Universit\u00e9 de Lyon Villeurbanne France"},{"name":"Laboratoire d\u2019Excellence du Globule Rouge (Labex GR\u2010Ex) PRES Sorbonne Paris 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