{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:06:10Z","timestamp":1775999170800,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900185"],"award-info":[{"award-number":["81900185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20353"],"award-info":[{"award-number":["U20A20353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Re\u2010activation of fetal haemoglobin (HbF) has been proved to be an effective strategy for the treatment of \u03b2\u2010haemoglobinopathies. In this study, we identified TEA domain transcription factor 4 (<jats:italic>TEAD4<\/jats:italic>) as a new potential regulator of HbF by integrating public data sets with quantitative polymerase chain reaction analysis in \u03b2\u2010thalassaemia patients. Significant negative correlation was observed between the expression of <jats:italic>TEAD4<\/jats:italic> and HbF levels in \u03b2\u2010thalassaemia patients. Functional validations of <jats:italic>TEAD4<\/jats:italic> inhibition in both \u03b2\u2010thalassaemia CD34<jats:sup>+<\/jats:sup> cells and HUDEP\u20102 cells indicated that depletion of <jats:italic>TEAD4<\/jats:italic> led to a significant increase of HbF. Finally, we identified a binding motif of <jats:italic>TEAD4<\/jats:italic> on \u03b3\u2010globin gene promoters; its disruption consistently led to de\u2010repression of HbF. Taken together, these results demonstrate that <jats:italic>TEAD4<\/jats:italic> could act as a transcriptional inhibitor of the \u03b3\u2010globin gene through direct binding on its promoter. Our findings demonstrate a novel role of <jats:italic>TEAD4<\/jats:italic> on the regulation of HbF, which may benefit patients with \u03b2\u2010haemoglobinopathies.<\/jats:p>","DOI":"10.1111\/bjh.17786","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T12:29:26Z","timestamp":1632745766000},"page":"764-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the \u03b3\u2010globin gene promoters"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7094-159X","authenticated-orcid":false,"given":"Jiaqiong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medical Genetics School of Basic Medical Sciences Southern Medical University 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