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In the present study, we investigated baseline 9p24.1 status as well as PD\u2010L1 and major histocompatibility complex (MHC) class I and II protein expression in 82 biopsies from patients with early stage unfavourable cHL treated with anti\u2010PD\u20101\u2010based first\u2010line treatment in the German Hodgkin Study Group (GHSG) NIVAHL trial (ClinicalTrials.gov Identifier: NCT03004833). All evaluated specimens showed 9p24.1 CNA in HRSC to some extent, but with high intratumoral heterogeneity and an overall smaller range of alterations than reported in advanced\u2010stage or r\/r cHL. All but two cases (97%) showed PD\u2010L1 expression by the tumour cells in variable amounts. While MHC\u2010I was rarely expressed in &gt;50% of HRSC, MHC\u2010II expression in &gt;50% of HRSC was found more frequently. No obvious impact of 9p24.1 CNA or PD\u2010L1 and MHC\u2010I\/II expression on early response to the highly effective anti\u2010PD\u20101\u2010based NIVAHL first\u2010line treatment was observed. Further studies evaluating an expanded panel of potential biomarkers are needed to optimally stratify anti\u2010PD\u20101 first\u2010line cHL treatment.<\/jats:p>","DOI":"10.1111\/bjh.17793","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T13:20:51Z","timestamp":1631625651000},"page":"116-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["9p24.1 alterations and programmed cell death 1 ligand 1 expression in early stage unfavourable classical Hodgkin lymphoma: an analysis from the German Hodgkin Study Group NIVAHL trial"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-2774","authenticated-orcid":false,"given":"Elena","family":"Gerhard\u2010Hartmann","sequence":"first","affiliation":[{"name":"Institute of Pathology University of W\u00fcrzburg W\u00fcrzburg Germany"},{"name":"Comprehensive Cancer Center Mainfranken W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Goergen","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Faculty of Medicine and University Hospital of Cologne Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) and German Hodgkin Study Group (GHSG) University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Br\u00f6ckelmann","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Faculty of Medicine and University Hospital of Cologne Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) and German Hodgkin Study Group (GHSG) University of Cologne Cologne Germany"},{"name":"Faculty of Medicine and University Hospital of Cologne Mildred Scheel School of Oncology Aachen Bonn Cologne D\u00fcsseldorf (MSSO ABCD) Cologne 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