{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:14:36Z","timestamp":1776899676386,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Transfusion\u2010associated graft\u2010<jats:italic>versus<\/jats:italic>\u2010host disease (TA\u2010GVHD) is a rare, commonly fatal complication of transfusion preventable by irradiation of blood units. The revision of the Dutch transfusion guideline addressed the question whether irradiation is still necessary if blood components are prestorage leukodepleted. We searched for published cases of TA\u2010GVHD following transfusion of prestorage leukodepleted blood and through contacting haemovigilance systems. Six presumed cases were found, dating from 1998 to 2013. Four out of six patients had received one or more non\u2010irradiated units despite recognised indications for irradiated blood components. In the countries providing information, over 50 million prestorage leukodepleted, non\u2010irradiated, non\u2010pathogen\u2010reduced cellular components were transfused in a 10\u2010year period. Potential benefits of lifting indications for irradiation were considered. These include reduced irradiation costs (\u20ac 1.5 million annually in the Netherlands) and less donor exposure for neonates. Findings were presented in an invitational expert meeting. Recommendations linked to human leukocyte antigen similarity between donor and recipient or intra\u2010uterine transfusion were left unchanged. Indications linked to long\u2010lasting deep T\u2010cell suppression were defined with durations of 6 or 12 months after end of treatment (e.g. autologous or allogeneic stem cell transplantation). Need for continued alertness to TA\u2010GVHD and haemovigilance reporting of erroneous non\u2010irradiated transfusions was emphasised.<\/jats:p>","DOI":"10.1111\/bjh.17822","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T01:59:01Z","timestamp":1630979941000},"page":"681-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Guideline development for prevention of transfusion\u2010associated graft\u2010<i>versus<\/i>\u2010host disease: reduction of indications for irradiated blood components after prestorage leukodepletion of blood components"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-9911","authenticated-orcid":false,"given":"Johanna C.","family":"Wiersum\u2010Osselton","sequence":"first","affiliation":[{"name":"TRIP (Transfusion and Transplantation Reactions in Patients) Hemovigilance and Biovigilance Office Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennichjen","family":"Slomp","sequence":"additional","affiliation":[{"name":"Medlon\u2010Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Frederik Falkenburg","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"Geltink","sequence":"additional","affiliation":[{"name":"Knowledge Institute of Medical Specialists Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans L. P.","family":"van Duijnhoven","sequence":"additional","affiliation":[{"name":"Elkerliek Ziekenhuis Helmond The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Netelenbos","sequence":"additional","affiliation":[{"name":"Haga Teaching Hospital The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Schipperus","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center UMCG Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0620-RS"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.10.2096.2096"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-620872"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01281.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12081"},{"key":"e_1_2_10_8_1","unstructured":"Bolton\u2010MaggsPHB PolesD WattA ThomasD CohenH&Serious Hazards of Transfusion (SHOT) Steering Group; on behalf of the . The 2012 annual SHOT report. 2013. Available from:https:\/\/www.shotuk.org\/wp\u2010content\/uploads\/myimages\/SHOT\u2010Annual\u2010Report\u201020121.pdf"},{"key":"e_1_2_10_9_1","unstructured":"TRIP reports on haemovigilance extended version. Available from:https:\/\/www.tripnet.nl\/en\/publications\/trip\u2010reports\/"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08444.x"},{"key":"e_1_2_10_11_1","unstructured":"Dutch transfusion guideline available (in Dutch). Available from:https:\/\/richtlijnendatabase.nl\/richtlijn\/bloedtransfusiebeleid\/startpagina_\u2010_bloedtransfusiebeleid.html"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363523"},{"key":"e_1_2_10_13_1","unstructured":"European Directorate for the Quality of Medicines and Healthcare.Reports on the collection testing and use of blood and blood components in Europe. Available from:https:\/\/www.edqm.eu\/en\/blood\u2010transfusion\u2010reports\u201070.html"},{"key":"e_1_2_10_14_1","article-title":"Missed irradiation of cellular blood components for vulnerable patients: Insights from 10 years of SHOT data","author":"Elliot J","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121256"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39299154725.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02789.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196909252811303"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901201)66:11<2346::AID-CNCR2820661116>3.0.CO;2-T"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17016"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2012.01662.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:13:48Z","timestamp":1693210428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,6]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/bjh.17822"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17822","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,6]]},"assertion":[{"value":"2021-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}