{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:20:02Z","timestamp":1778545202892,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with classical Hodgkin lymphoma (cHL) who do not achieve complete remission (CR) after second\u2010line chemotherapy have poor clinical outcomes. Besides, conventional salvage chemotherapy regimens have an unsatisfactory CR rate. The present retrospective study reports the efficacy and toxicity of the GVD (gemcitabine, vinorelbine, liposomal doxorubicin) regimen with or without programmed cell death 1 (PD\u20101) inhibitor for patients with cHL who failed first\u2010line treatment. A total of 103 patients with cHL (GVD+PD\u20101 group, <jats:italic>n<\/jats:italic>\u2009=\u200927; GVD group, <jats:italic>n<\/jats:italic>\u2009=\u200976) with response assessment based on positron emission tomography were included. The GVD+PD\u20101 group tended to have a higher CR rate than GVD group (85\u00b72% vs. 65\u00b78%, <jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7057) and had a better event\u2010free survival (EFS) (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7034). Subgroup analysis showed that patients with low\u2010risk second\u2010line International Prognostic Score might benefit from the addition of PD\u20101 inhibitor (GVD+PD\u20101 vs. GVD, 100\u00b70% vs. 64\u00b77%, <jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7028) and had better EFS than GVD alone (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7016). Further analysis demonstrated that PD\u20101 consolidation therapy might provide an EFS benefit (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7007). The toxicity of the GVD+PD\u20101 regimen was comparable to the GVD regimen, except for higher rates of hypothyroidism and autoimmune pneumonitis, which were manageable. In conclusion, combining a PD\u20101 inhibitor with a GVD regimen could be a potentially effective second\u2010line therapy for patients with cHL.<\/jats:p>","DOI":"10.1111\/bjh.17849","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T18:59:20Z","timestamp":1633805960000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combination of PD\u20101 inhibitor with GVD (gemcitabine, vinorelbine, liposomal doxorubicin) <i>versus<\/i> GVD regimen as second\u2010line therapy for relapsed\/refractory classical Hodgkin lymphoma"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-1520","authenticated-orcid":false,"given":"Yu\u2010Chen","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. 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