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MPNs encompass a spectrum of disorders with overlapping but distinct molecular, laboratory and clinical features. This includes polycythaemia vera, essential thrombocythaemia and myelofibrosis. Dysregulation of the immune system is key to the pathology of MPNs, supporting clonal evolution, mediating symptoms and resulting in varying degrees of immunocompromise. Targeting immune dysfunction is an important treatment strategy. In the present review, we focus on the immune landscape in patients with MPNs \u2013 the role of inflammation in disease pathogenesis, susceptibility to infection and emerging strategies for therapeutic immune modulation. Further detailed work is required to delineate immune perturbation more precisely in MPNs to determine how and why vulnerability to infection differs between clinical subtypes and to better understand how inflammation results in a competitive advantage for the MPN clone. These studies may help shed light on new designs for disease\u2010modifying therapies.<\/jats:p>","DOI":"10.1111\/bjh.17850","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T18:51:25Z","timestamp":1633805485000},"page":"1149-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The immune landscape in BCR\u2010ABL negative myeloproliferative neoplasms: inflammation, infections and opportunities for immunotherapy"],"prefix":"10.1111","volume":"196","author":[{"given":"Marie","family":"Strickland","sequence":"first","affiliation":[{"name":"MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine, University of Oxford Oxford"},{"name":"National Institutes for Health Research Biomedical Research Centre University of Oxford 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