{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:37:59Z","timestamp":1793929079607,"version":"4.8.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>It is unclear how treatment advances impacted the population\u2010level survival of patients with lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinaemia (LPL\/WM). Therefore, we assessed trends in first\u2010line therapy and relative survival (RS) among patients with LPL\/WM diagnosed in the Netherlands between 1989 and 2018 (<jats:italic>N<\/jats:italic>\u00a0=\u00a06232; median age, 70\u00a0years; 61% males) using data from the nationwide Netherlands Cancer Registry. Patients were grouped into three age groups (&lt;65, 66\u201375 and &gt;75\u00a0years) and four calendar periods. Overall, treatment with anti\u2010neoplastic agents within 1\u00a0year post\u2010diagnosis gradually decreased over time, following a broader application of an initial watch\u2010and\u2010wait approach. Approximately 40% of patients received anti\u2010neoplastic therapy during 2011\u20132018. Furthermore, use of chemotherapy alone decreased over time, following an increased application of chemoimmunotherapy. Detailed data among 1596 patients diagnosed during 2014\u20132018 revealed that dexamethasone\u2010rituximab\u2010cyclophosphamide was the most frequently applied regimen; its use increased from 14% to 39% between 2014 and 2018. The 5\u2010year RS increased significantly over time, particularly since the introduction of rituximab in the early\u2013mid 2000s. The 5\u2010year RS during 1989\u20131995 was 75%, 65%, and 46% across the age groups compared to 93%, 85%, and 79% during 2011\u20132018. However, the survival improvement was less pronounced after 2011. Collectively, the impressive survival improvement may be accounted for by broader application of rituximab\u2010containing therapy. The lack of survival improvement in the post\u2010rituximab era warrants studies across multiple lines of therapy to further improve survival in LPL\/WM.<\/jats:p>","DOI":"10.1111\/bjh.17856","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T07:30:51Z","timestamp":1633419051000},"page":"660-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Primary therapy and relative survival in patients with lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinaemia: a population\u2010based study in the Netherlands, 1989\u20132018"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2865-7608","authenticated-orcid":false,"given":"Karima","family":"Amaador","sequence":"first","affiliation":[{"name":"Amsterdam UMC Department of Hematology University of Amsterdam Cancer Center Amsterdam LYMMCARE Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Jos\u00e9","family":"Kersten","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Department of Hematology University of Amsterdam Cancer Center Amsterdam LYMMCARE Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Registration Netherlands Comprehensive Cancer Organisation (IKNL) Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Brink","sequence":"additional","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL) Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardus F. 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I.","family":"Vos","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Department of Hematology University of Amsterdam Cancer Center Amsterdam LYMMCARE Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4767-6716","authenticated-orcid":false,"given":"Avinash G.","family":"Dinmohamed","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Department of Hematology University of Amsterdam Cancer Center Amsterdam LYMMCARE Amsterdam the Netherlands"},{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL) Utrecht the Netherlands"},{"name":"Department of Public Health Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands"},{"name":"Amsterdam UMC Department of Hematology Vrije Universiteit Amsterdam Cancer Center Amsterdam Amsterdam the 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