{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:12:50Z","timestamp":1769184770373,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001452","name":"Institute of Chemical and Engineering Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Survival disparities by locus of care (LOC; paediatric <jats:italic>versus<\/jats:italic> adult) among adolescents and young adults (AYA) with acute lymphoblastic leukaemia (ALL) are well documented. Whether similar disparities exist among AYA with aggressive mature B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL) is unknown. We identified all Ontario, Canada AYA aged 15\u201321\u00a0years at diagnosis of B\u2010NHL between 1992 and 2012. Demographic, disease, treatment and outcome data were chart abstracted. The impact of LOC on event\u2010free (EFS) and overall survival (OS) were determined, adjusted for patient and disease covariates. Among 176 AYA with B\u2010NHL, 62 (35\u00b72%) received therapy at paediatric centres. The 5\u2010year EFS and OS [\u00b1 standard error (SE)] for the overall cohort were 72\u00b72\u00a0[3\u00b74]% and 76\u00b71\u00a0[3\u00b72]% respectively. Both EFS and OS were superior among paediatric centre AYA [EFS\u00a0(\u00b1\u00a0SE) 82\u00b72\u00a0(4\u00b79)% vs. 66\u00b77\u00a0(4\u00b74)%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702; OS 85\u00b75\u00a0(4\u00b75)% vs. 71\u00b71\u00a0(4\u00b73)%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703]. Adjusted for histology, stage and time period, adult centre AYA had inferior EFS [hazard ratio (HR) 2\u00b74, 95% confidence interval (CI) 1\u00b71\u20134\u00b79, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702] and OS (HR 2\u00b75, 95% CI 1\u00b71\u20135\u00b77, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703). Sensitivity analyses restricted to the latest time period, when most adult centre AYA received rituximab, demonstrated similar disparities. Similar to AYA with ALL, AYA with B\u2010NHL may benefit from being treated with paediatric protocols. Studies prospectively validating these results are warranted.<\/jats:p>","DOI":"10.1111\/bjh.17862","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T14:50:34Z","timestamp":1633186234000},"page":"743-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Superior outcomes with paediatric protocols in adolescents and young adults with aggressive B\u2010cell non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-3670","authenticated-orcid":false,"given":"Sumit","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto ON Canada"},{"name":"Cancer Research Program ICES Toronto ON Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto Toronto ON Canada"},{"name":"Faculty of Medicine University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Pole","sequence":"additional","affiliation":[{"name":"Cancer Research Program ICES Toronto ON Canada"},{"name":"Center for Health Services Research University of Queensland Brisbane Australia"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinku","family":"Sutradhar","sequence":"additional","affiliation":[{"name":"Cancer Research Program ICES Toronto ON Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto Toronto ON Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Crump","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Haematology Princess Margaret Cancer Centre\u2010University Health Network Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenthila","family":"Nagamuthu","sequence":"additional","affiliation":[{"name":"Cancer Research Program ICES Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy N.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Cancer Research Program ICES Toronto ON Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto Toronto ON Canada"},{"name":"Li Ka Shing Knowledge Institute St. Michael\u2019s Hospital Toronto ON Canada"},{"name":"Melbourne School of Population and Global Health University of Melbourne Carlton Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto ON Canada"},{"name":"Cancer Research Program ICES Toronto ON Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto Toronto ON Canada"},{"name":"Faculty of Medicine University of Toronto Toronto ON 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