{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:33:53Z","timestamp":1790393633714,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["407495230"],"award-info":[{"award-number":["407495230"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["423957469"],"award-info":[{"award-number":["423957469"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sporadic Burkitt lymphoma (BL) is the most frequent tumour of children and adolescents but a rare subtype of lymphomas in adults. To date most molecular data have been obtained from lymphomas arising in the young. Recently, Epstein\u2013Barr virus (EBV) positive and negative BL in young patients was shown to differ in molecular features. In the present study, we present a large age\u2010overarching cohort of sporadic BL (<jats:italic>n<\/jats:italic>\u00a0=\u00a0162) analysed by immunohistochemistry, translocations of MYC proto\u2010oncogene, basic helix\u2010loop\u2010helix transcription factor (<jats:italic>MYC<\/jats:italic>), B\u2010cell leukaemia\/lymphoma 2 (<jats:italic>BCL2<\/jats:italic>) and B\u2010cell leukaemia\/lymphoma 6 (<jats:italic>BCL6<\/jats:italic>) and by targeted sequencing. We illustrate an age\u2010associated inter\u2010tumoral molecular heterogeneity in this disease. Mutations affecting inhibitor of DNA binding 3, HLH protein (<jats:italic>ID3<\/jats:italic>), transcription factor 3 (<jats:italic>TCF3<\/jats:italic>) and cyclin D3 (<jats:italic>CCND3<\/jats:italic>), which are highly recurrent in paediatric BL, and expression of sex determining region Y\u2010box transcription factor 11 (SOX11) declined with patient age at diagnosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70204 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70197 respectively). In contrast, EBV was more frequently detected in adult patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70262). Irrespective of age, EBV\u2010positive sporadic BL showed significantly less frequent mutations in <jats:italic>ID3<\/jats:italic>\/<jats:italic>TCF3<\/jats:italic>\/<jats:italic>CCND3<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70088) but more often mutations of G protein subunit alpha 13 (<jats:italic>GNA13<\/jats:italic>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70368) and forkhead box O1 (<jats:italic>FOXO1<\/jats:italic>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70044) compared to EBV\u2010negative tumours. Our findings suggest that among sporadic BL an EBV\u2010positive subgroup of lymphomas increases with patient age that shows distinct pathogenic features reminiscent of EBV\u2010positive endemic BL.<\/jats:p>","DOI":"10.1111\/bjh.17874","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:56:29Z","timestamp":1633740989000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Epstein\u2013Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-4084","authenticated-orcid":false,"given":"Julia","family":"Richter","sequence":"first","affiliation":[{"name":"Department of Pathology Hematopathology Section\u00a0and Lymph Node Registry Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pathology Hematopathology Section\u00a0and Lymph Node Registry Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"Staiger","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Krankenhaus Stuttgart Germany"},{"name":"Dr. Margarete Fischer\u2010Bosch Institute of Clinical Pharmacology University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology University W\u00fcrzburg and Comprehensive Cancer Mainfranken W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kurz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Krankenhaus Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Michgehl","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-6793","authenticated-orcid":false,"given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Krankenhaus Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"Franzenburg","sequence":"additional","affiliation":[{"name":"Institute for Clinical Molecular Biology University of Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kohler","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Finger","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilske","family":"Oschlies","sequence":"additional","affiliation":[{"name":"Department of Pathology Hematopathology Section\u00a0and Lymph Node Registry Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Pathology Hematopathology Section\u00a0and Lymph Node Registry Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Spang","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-829X","authenticated-orcid":false,"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-4117","authenticated-orcid":false,"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Department of Pathology Hematopathology Section\u00a0and Lymph Node Registry Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-767335"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-16-0305"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11443"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2469"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-871418"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11378"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2468"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1365851"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388470"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000332"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-136465"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-349662"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005158"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqv011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03022-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16578"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-508937"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03050-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08578-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.156885"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001880"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018029546"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa371"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13624"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000804"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1258701"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2986"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-776278"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-703819"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.271957"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14812"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-507996"},{"key":"e_1_2_8_38_1","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","year":"2018"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1907374"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.355"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-438937"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3413"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:42:18Z","timestamp":1692830538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/bjh.17874"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17874","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]},"assertion":[{"value":"2021-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}