{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:19:57Z","timestamp":1791688797320,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients affected by lymphoid malignancies (LM) are frequently immune\u2010compromised, suffering increased mortality from COVID\u201019. This prospective study evaluated serological and T\u2010cell responses after complete mRNA vaccination in 263 patients affected by chronic lymphocytic leukaemia, B\u2010 and T\u2010cell lymphomas and multiple myeloma. Results were compared with those of 167 healthy subjects matched for age and sex. Overall, patient seroconversion rate was 64\u00b76%: serological response was lower in those receiving anti\u2010cancer treatments in the 12\u00a0months before vaccination: 55% vs 81\u00b79% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Anti\u2010CD20 antibody plus chemotherapy treatment was associated with the lowest seroconversion rate: 17\u00b76% vs. 71\u00b72% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). In the multivariate analysis conducted in the subgroup of patients on active treatment, independent predictors for seroconversion were: anti\u2010CD20 treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), aggressive B\u2010cell lymphoma diagnosis (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7002), and immunoglobulin M levels &lt;40\u00a0mg\/dl (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7030). The T\u2010cell response was evaluated in 99 patients and detected in 85 of them (86%). Of note, 74% of seronegative patients had a T\u2010cell response, but both cellular and humoral responses were absent in 13\u00b71% of cases. Our findings raise some concerns about the protection that patients with LM, particularly those receiving anti\u2010CD20 antibodies, may gain from vaccination. These patients should strictly maintain all the protective measures.<\/jats:p>","DOI":"10.1111\/bjh.17877","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T20:20:14Z","timestamp":1634674814000},"page":"548-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["T\u2010cell immune response after mRNA SARS\u2010CoV\u20102 vaccines is frequently detected also in the absence of seroconversion in patients with lymphoid malignancies"],"prefix":"10.1111","volume":"196","author":[{"given":"Vincenzo","family":"Marasco","sequence":"first","affiliation":[{"name":"School of Medicine University of Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-1757","authenticated-orcid":false,"given":"Cristiana","family":"Carniti","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Guidetti","sequence":"additional","affiliation":[{"name":"School of Medicine University of Milano Italy"},{"name":"Division of Hematology Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Farina","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Magni","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Miceli","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Trial Organization Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Calabretta","sequence":"additional","affiliation":[{"name":"School of Medicine University of Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Verderio","sequence":"additional","affiliation":[{"name":"Unit of Bioinformatics and Biostatistics Department of Applied Research and Technological Development Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Ljevar","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Trial Organization Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Serpenti","sequence":"additional","affiliation":[{"name":"School of Medicine University of Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Apolone","sequence":"additional","affiliation":[{"name":"Scientific Directorate Fondazione IRCCS Istituto Nazionale dei Tumori Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ippolito","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \"Lazzaro Spallanzani\" I.R.C.C.S Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Agrati","sequence":"additional","affiliation":[{"name":"Cellular Immunology Laboratory INMI L Spallanzani Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-1353","authenticated-orcid":false,"given":"Paolo","family":"Corradini","sequence":"additional","affiliation":[{"name":"School of Medicine University of Milano Italy"},{"name":"Division of Hematology Fondazione IRCCS Istituto Nazionale dei Tumori Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30251-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-020-00177-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008824"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01330-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17704"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-372649"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01793.x"},{"key":"e_1_2_9_12_1","first-page":"1465","article-title":"Vaccines for prophylaxis of viral infections in patients with hematological malignancies","volume":"3","author":"Cheuk DKL","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.12.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30600-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30601-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9061315"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01386-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003170"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.3.4.214"},{"key":"e_1_2_9_20_1","first-page":"1","article-title":"Safety and immunogenicity of one versus two doses of the COVID\u201019 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study","author":"Monin L","year":"2021","journal-title":"Lancet Oncol"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01090-6"},{"issue":"21","key":"e_1_2_9_22_1","first-page":"19","article-title":"Response to first vaccination against SARS\u2010CoV\u20102 in patients with multiple myeloma","volume":"3026","author":"Bird S","year":"2021","journal-title":"Lancet Haematol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011568"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2017.1392562"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0612-x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V110.11.2371.2371"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.2437"},{"key":"e_1_2_9_28_1","first-page":"7","article-title":"Immune reconstitution after allogeneic hematopoietic stem cell transplantation","volume":"17","author":"Ogonek J","year":"2016","journal-title":"Front Immunol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.254045"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1221"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00530-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004095"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl141"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8511"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.08.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0402-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2108861"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:42:16Z","timestamp":1692830536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,14]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/bjh.17877"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17877","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,14]]},"assertion":[{"value":"2021-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}