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Because response to reinduction is predictive of the outcome after HDCT\u00a0+\u00a0ASCT, we aimed to improve the standard dexamethasone, high\u2010dose cytarabine and cisplatinum (DHAP) reinduction regimen by addition of the oral mammalian target of rapamycin inhibitor everolimus (everDHAP). Transplant\u2010eligible patients aged 18\u201360\u00a0years with histologically confirmed r\/r cHL were included in this experimental phase I\/II trial. Everolimus (10\u00a0mg\/day, determined in phase\u2010I\u2010part) was administered on day 0\u201313 of each DHAP cycle. From July 2014 to March 2018, 50 patients were recruited to the phase II everDHAP group; two were not evaluable, three discontinued due to toxicity. Randomization to a placebo group stopped in October 2015 due to poor recruitment after nine patients. The primary end\u2010point of computed tomography (CT)\u2010based complete remission (CR) after two cycles of everDHAP was expected to be \u226540%. With a CT\u2010based CR rate of 27% (<jats:italic>n<\/jats:italic>\u00a0=\u00a012\/45) after two cycles of everDHAP the trial did not meet the primary end\u2010point. Adding everolimus to DHAP is thus feasible; however, the everDHAP regimen failed to show an improved efficacy.<\/jats:p>","DOI":"10.1111\/bjh.17878","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T15:34:43Z","timestamp":1636904083000},"page":"606-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reinduction therapy with everolimus in combination with dexamethasone, high\u2010dose cytarabin and cisplatinum in patients with relapsed or refractory classical Hodgkin lymphoma: an experimental phase I\/II multicentre trial of the German Hodgkin Study Group (GHSG HD\u2010R3i)"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3114-3787","authenticated-orcid":false,"given":"Sarah","family":"Gillessen","sequence":"first","affiliation":[{"name":"German Hodgkin Study Group (GHSG) Department I of Internal Medicine Center for Integrated Oncology 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