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Severe pain and fatigue symptoms and impairments in physical and emotional functioning have been strongly linked to reduced health\u2010related quality of life (HRQoL) in patients with RRMM. Assessment of patient reported\u2010outcome measures from the pivotal, Phase II HORIZON study (OP\u2010106; NCT02963493) in patients with RRMM (<jats:italic>n<\/jats:italic>\u00a0=\u00a064) demonstrated that melphalan flufenamide (melflufen) plus dexamethasone treatment preserved HRQoL. Patients had clinically meaningful improvements, even after eight treatment cycles, in relevant scales such as global health status\/QoL, physical functioning, emotional functioning, pain, and fatigue. Patients with triple\u2010class\u2013refractory disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a050) displayed similar improvements. Patient\u2010reported outcome deterioration was delayed for a substantial amount of time in patients who experienced a response to melflufen plus dexamethasone treatment relative to patients who did not experience a response. These findings support the notion that treatment with melflufen plus dexamethasone may sustain or improve HRQoL over time in patients with RRMM, including in patients with triple\u2010class\u2013refractory disease for whom outcomes are generally worse. The clinical benefits observed in patients from the HORIZON trial are encouraging and supportive of translation into real\u2010world practice.<\/jats:p>","DOI":"10.1111\/bjh.17887","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T14:29:36Z","timestamp":1634826576000},"page":"639-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Patient\u2010reported outcomes in relapsed\/refractory multiple myeloma treated with melflufen plus dexamethasone: analyses from the Phase II HORIZON study"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2070-3702","authenticated-orcid":false,"given":"Alessandra","family":"Larocca","sequence":"first","affiliation":[{"name":"Myeloma Unit Division of Hematology University of Torino Azienda Ospedaliero \u2013 Universitaria Citt\u00e0 della Salute e della Scienza Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Leleu","sequence":"additional","affiliation":[{"name":"CHU de Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-2575","authenticated-orcid":false,"given":"Cyrille","family":"Touzeau","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Nantes\u2010Angers (CRCINA) Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Centre National de la Recherche Scientifique (CNRS) Universit\u00e9 d\u2019Angers Universit\u00e9 de Nantes Nantes France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer (SIRIC), Imaging and Longitudinal Investigations to Ameliorate Decision\u2010making (ILIAD) Nantes France"},{"name":"Service d\u2019H\u00e9matologie Clinique Centre Hospitalier Universitaire Place Alexis Ricordeau Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Blad\u00e9","sequence":"additional","affiliation":[{"name":"Hematology Department IDIBAPS, Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agne","family":"Paner","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-1218","authenticated-orcid":false,"given":"Mar\u00eda\u2010Victoria","family":"Mateos","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Salamanca\/IBSAL\/CIC Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cavo","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Maisel","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Charles A. 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