{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:55:02Z","timestamp":1785927302419,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\u2018Monitoring of immune responses following mogamulizumab\u2010containing treatment in patients with adult T\u2010cell leukaemia\u2013lymphoma (ATL)\u2019 (MIMOGA) is a multicentre prospective clinical study (UMIN000008696). In the MIMOGA study, we found that a lower percentage of CD2<jats:sup>\u2212<\/jats:sup>CD19<jats:sup>+<\/jats:sup> B cells in peripheral blood mononuclear cells (PBMC) was a significant unfavourable prognostic factor for overall survival (OS). Accordingly, we then analysed the immunoglobulin G (IgG) heavy\u2010chain repertoire in PBMC by high\u2010throughput sequencing. Of the 101 patients enrolled in the MIMOGA study, for 81 a sufficient amount of PBMC RNA was available for repertoire sequencing analysis. Peripheral IgG B cells in patients with ATL had a restricted repertoire relative to those in healthy individuals. There was a significant positive correlation between the Shannon\u2013Weaver diversity index (SWDI) for the IgG repertoire and proportions of B cells in the PBMC of the patients. Multivariate analysis identified two variables significantly affecting OS: a higher serum soluble interleukin\u20102 receptor level, and a lower SWDI for the IgG repertoire [hazard ratio, 2\u00b7124; 95% confidence interval, 1\u00b7114\u20134\u00b7049; <jats:italic>n<\/jats:italic>\u00a0=\u00a044]. The present study documents the importance of humoral immune responses in patients receiving mogamulizumab\u2010containing treatment. Further investigation of strategies to enhance humoral immune responses in patients with ATL is warranted.<\/jats:p>","DOI":"10.1111\/bjh.17895","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T11:19:17Z","timestamp":1633951157000},"page":"629-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical significance of the immunoglobulin G heavy\u2010chain repertoire in peripheral blood mononuclear cells of adult T\u2010cell leukaemia\u2013lymphoma patients receiving mogamulizumab"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-2451","authenticated-orcid":false,"given":"Kisato","family":"Nosaka","sequence":"first","affiliation":[{"name":"Cancer Center Kumamoto University Hospital Kumamoto 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