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We present a high\u2010risk case of B\u2010cell ALL (B\u2010ALL) where retrospective mRNA sequencing identified a novel <jats:italic>GOLGA4\u2013JAK2<\/jats:italic> fusion gene. Expression of <jats:italic>GOLGA4\u2013JAK2<\/jats:italic> in murine pro\u2010B cells promoted factor\u2010independent growth, implicating <jats:italic>GOLGA4\u2013JAK2<\/jats:italic> as an oncogenic driver. Cells expressing <jats:italic>GOLGA4\u2013JAK2<\/jats:italic> demonstrated constitutive activation of JAK\/STAT signalling and were sensitive to JAK inhibitors. This study contributes to the diverse collection of <jats:italic>JAK2<\/jats:italic> fusion genes identified in B\u2010ALL and supports the incorporation of JAK inhibitors into treatment strategies to improve outcomes for this subtype.<\/jats:p>","DOI":"10.1111\/bjh.17910","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T03:20:00Z","timestamp":1635218400000},"page":"700-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of a novel <i>GOLGA4\u2013JAK2<\/i> fusion gene in B\u2010cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-836X","authenticated-orcid":false,"given":"Charlotte E. 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Medical Research Institute (SAHMRI) Adelaide SA Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide SA Australia"},{"name":"Department of Haematology Royal Adelaide Hospital and SA Pathology Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-4127","authenticated-orcid":false,"given":"Barbara J.","family":"McClure","sequence":"additional","affiliation":[{"name":"Cancer Program Precision Medicine Theme South Australian Health &amp; Medical Research Institute (SAHMRI) Adelaide SA Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4844-333X","authenticated-orcid":false,"given":"Deborah L.","family":"White","sequence":"additional","affiliation":[{"name":"Cancer Program Precision Medicine Theme South Australian Health &amp; 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