{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:01:38Z","timestamp":1760821298206,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We analysed long\u2010term outcome of patients receiving haematopoietic allogeneic stem cell transplantation (allo\u2010HSCT) as a first transplant for high\u2010risk Hodgkin lymphoma (HL). One hundred and ninety patients were included in this study, 63% of them had previously received brentuximab vedotin and\/or checkpoint inhibitors. Seventy patients (37%) received an unrelated donor allo\u2010HSCT, 99 (51%) had myeloablative conditioning (MAC) and 60% had <jats:italic>in\u2009vivo<\/jats:italic> T\u2010cell\/depleted grafts (TCD). The 100\u2010day cumulative incidence (CI) of grade II\u2010IV acute graft\u2010versus\u2010host disease (GVHD) was 25% and the 3\u2010year CI of chronic GVHD was 38%. The 3\u2010year CI of non\u2010relapse mortality (NRM) and relapse rate were 21% and 38% respectively. After a median follow\u2010up of 58\u2009months, 3\u2010year overall survival (OS) and progression\u2010free survival (PFS) were 58% and 41% respectively. Multivariate analysis showed that, in comparison to reduced\u2010intensity conditioning regimens with or without TCD, MAC using TCD had similar NRM and a lower risk of relapse leading to significantly better OS and PFS. MAC without TCD was associated with higher NRM and worse survival outcomes. These results suggest that in patients with high\u2010risk HL and candidates of allo\u2010HSCT, a MAC strategy with TCD might be the best option.<\/jats:p>","DOI":"10.1111\/bjh.17939","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T04:44:37Z","timestamp":1636433077000},"page":"1018-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term outcome of patients receiving haematopoietic allogeneic stem cell transplantation as first transplant for high\u2010risk Hodgkin lymphoma: a retrospective analysis from the Lymphoma Working Party\u2010EBMT"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-8279","authenticated-orcid":false,"given":"G.","family":"Guti\u00e9rrez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Haematology Bone Marrow Transplantation Unit Hospital Clinic of Barcelona University of Barcelona Institut de Recerca Biom\u00e8dica August Pi i Sunyer Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-7306","authenticated-orcid":false,"given":"C.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Haematology Bone Marrow Transplantation Unit Hospital Clinic of Barcelona University of Barcelona Institut de Recerca Biom\u00e8dica August Pi i Sunyer Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Boumendil","sequence":"additional","affiliation":[{"name":"Lymphoma Working Party EBMT Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Finel","sequence":"additional","affiliation":[{"name":"Lymphoma Working Party EBMT Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Malladi","sequence":"additional","affiliation":[{"name":"School of Cancer Sciences, University of Birmingham Centre for Clinical Haematology, Queen Elizabeth NHS Foundation Trust Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Afanasyev","sequence":"additional","affiliation":[{"name":"State Medical Pavlov University St.\u00a0Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tsoulkani","sequence":"additional","affiliation":[{"name":"Nottingham City Hospital Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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