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The MRD load was monitored by immunoglobulin\/T\u2010cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non\u2010quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5\u2010year overall survival for CMR, MRDnq and MRDq at week 11 was 74\u00b70%, 42\u00b73% and 35\u00b70% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0\u00b732 and 2\u00b725).<\/jats:p>","DOI":"10.1111\/bjh.17966","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T05:34:46Z","timestamp":1637732086000},"page":"706-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low levels of minimal residual disease after induction chemotherapy for <i>BCR\u2010ABL1<\/i>\u2010negative acute lymphoblastic leukaemia in adults are clinically relevant"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-3247","authenticated-orcid":false,"given":"Cyril","family":"\u0160\u00e1lek","sequence":"first","affiliation":[{"name":"Institute of Haematology and Blood Transfusion Prague Czech Republic"},{"name":"Institute of Clinical and Experimental Haematology First 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