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To identify potential new treatments for TAM, we performed <jats:italic>in\u00a0vitro<\/jats:italic> drug sensitivity testing (DST) using the peripheral blood samples of eight patients with TAM. DST screened 41 agents for cytotoxic properties against TAM blasts. Compared with the reference samples of healthy subjects, TAM blasts were more sensitive to glucocorticoids, the mitogen\u2010activated protein kinase kinase (MAP2K) inhibitor trametinib, and cytarabine. Our present results support the therapeutic potential of glucocorticoids and the role of the RAS\/MAP2K signalling pathway in TAM pathogenesis.<\/jats:p>","DOI":"10.1111\/bjh.17970","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T05:00:46Z","timestamp":1637730046000},"page":"764-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Using the <i>in\u00a0vitro<\/i> drug sensitivity test to identify candidate treatments for transient abnormal myelopoiesis"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6549-2999","authenticated-orcid":false,"given":"Tomoko","family":"Yokosuka","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Kanagawa Children\u2019s Medical Center Yokohama 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