{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:06:03Z","timestamp":1790665563751,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The prognostic role of\n                    <jats:italic>TP53<\/jats:italic>\n                    disruption has been established in diffuse large B\u2010cell lymphoma (DLBCL). Aim of this analysis was to correlate\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations by Sanger sequencing, cell of origin (COO) profile by Lymph2Cx panel on the NanoString platform and\n                    <jats:italic>MYC<\/jats:italic>\n                    ,\n                    <jats:italic>BCL2<\/jats:italic>\n                    and\n                    <jats:italic>BCL6<\/jats:italic>\n                    overexpression or re\u2010arrangements by immunohistochemistry (IHC) and fluorescent\n                    <jats:italic>in\u2010situ<\/jats:italic>\n                    hybridization (FISH), with outcome in DLBCL patients enrolled into the FIL\u2010DLCL04 trial (NCT00499018). One hundred and twenty\u2010five DLBCL patients with tumour block available were analyzed.\n                    <jats:italic>TP53<\/jats:italic>\n                    was mutated in 11\/125 (9%) cases; 60\/125 patients received high\u2010dose chemoimmunotherapy up\u2010front, as for the randomization arm; COO was reported in 88 patients: 48 germinal centre B\u2010cell like, 25 activated B\u2010cell like and 17 unclassified; 26 patients were double expressors in IHC and 11 double hit in FISH. After a median follow\u2010up of 72\u2009months, five\u2010year failure\u2010free survival (FFS) for\n                    <jats:italic>TP53<\/jats:italic>\n                    mutated\n                    <jats:italic>versus<\/jats:italic>\n                    wild\u2010type was 24% and 72%, and five\u2010year overall survival (OS) was 34% and 83%, respectively. Adjusted hazard ratio (HR) was 2\u00b728 [95% confidence interval (CI) 0\u00b789\u20135\u00b786,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090\u00b7086] and 4\u00b705 (95% CI 1\u00b737\u201311\u00b797,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090\u00b7011) for FFS and OS, respectively. In this series of young DLBCL patients,\n                    <jats:italic>TP53<\/jats:italic>\n                    gene mutation identified a poor prognosis subgroup, regardless of treatment and other biological markers.\n                  <\/jats:p>","DOI":"10.1111\/bjh.17971","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T20:49:05Z","timestamp":1640292545000},"page":"1184-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Prognostic impact of\n                    <i>TP53<\/i>\n                    mutation in newly diagnosed diffuse large B\u2010cell lymphoma patients treated in the FIL\u2010DLCL04 trial"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2977-0098","authenticated-orcid":false,"given":"Annalisa","family":"Chiappella","sequence":"first","affiliation":[{"name":"Hematology Azienda Ospedaliero\u2010Universitaria Citt\u00e0 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