{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:26:23Z","timestamp":1789010783999,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There are limited data on contemporary outcomes for women with sickle cell disease (SCD) in pregnancy. We conducted a single\u2010site matched cohort study, comparing 131 pregnancies to women with SCD between 2007 and 2017 to a comparison group of 1310 pregnancies unaffected by SCD. Restricting our analysis to singleton pregnancies that reached 24\u2009weeks of gestation, we used conditional Poisson regression to estimate adjusted risk ratios (aRRs) for perinatal outcomes. Infants born to mothers with SCD were more likely to be small for gestational age [aRR 1\u00b769, 95% confidence interval (CI) 1\u00b713\u20132\u00b748], preterm (aRR 2\u00b762, 95% CI 1\u00b782\u20133\u00b778) and require Neonatal Unit (NNU) admission (aRR 3\u00b759, 95% CI 2\u00b718\u20135\u00b790). Pregnant women with SCD were at higher risk of pre\u2010eclampsia\/eclampsia (aRR 3\u00b753, 95% CI 2\u00b700\u20136\u00b724), more likely to receive induction of labour (aRR 2\u00b750, 95% CI 1\u00b782\u20131\u00b776) and caesarean birth (aRR 1\u00b744, 95% CI 1\u00b718\u20131\u00b776). In analysis stratified by genotype, the risk of adverse outcomes was highest in haemoglobin SS (HbSS) pregnancies (<jats:italic>n<\/jats:italic>\u2009=\u200980). There was no strong evidence that haemoglobin SC (HbSC) pregnancies (<jats:italic>n<\/jats:italic>\u2009=\u200946) were at higher risk of preterm birth, caesarean delivery, or NNU admission. Pre\u2010eclampsia\/eclampsia was more frequently observed in HbSC pregnancies. Despite improvements in the care of pregnant women with SCD, the increased risk of adverse perinatal outcomes remains.<\/jats:p>","DOI":"10.1111\/bjh.17983","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T04:29:00Z","timestamp":1639024140000},"page":"1069-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Perinatal outcomes in women with sickle cell disease: a matched cohort study from London, UK"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4697-4316","authenticated-orcid":false,"given":"Laura L.","family":"Oakley","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health London School of Hygiene and Tropical Medicine London UK"},{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Women &amp; Children's Health Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez","family":"von Rege","sequence":"additional","affiliation":[{"name":"Department of Women &amp; Children's Health Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4020-8933","authenticated-orcid":false,"given":"Ruth","family":"Hadebe","sequence":"additional","affiliation":[{"name":"Department of Women &amp; Children's Health Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-6531","authenticated-orcid":false,"given":"Jo","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-5536","authenticated-orcid":false,"given":"Susan E.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-2909","authenticated-orcid":false,"given":"Eugene","family":"Oteng\u2010Ntim","sequence":"additional","affiliation":[{"name":"Department of Women &amp; Children's Health Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24235"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13270"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07330-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13786"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-607317"},{"key":"e_1_2_10_7_1","unstructured":"Royal College of Obstetricians & Gynaecologists. Sickle Cell Disease in Pregnancy Management of (Green\u2010top Guideline No. 61). 2011."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17671"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16518"},{"key":"e_1_2_10_10_1","volume-title":"The English indices of deprivation 2015","author":"Smith T","year":"2015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1101100208"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_10_13_1","first-page":"873","article-title":"Sickle cell and sickle cell\u2010hemoglobin C disease during pregnancy","volume":"39","author":"Horger EO","year":"1972","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.04.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.05.032"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16696"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000039"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2010.100026"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12626"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.11.018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogrm.2019.01.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12447"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.625"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-649319"},{"key":"e_1_2_10_26_1","article-title":"Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy","volume":"12","author":"Okusanya BO","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-4212-8"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:06:07Z","timestamp":1692849967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/bjh.17983"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17983","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,8]]},"assertion":[{"value":"2021-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}