{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:53:29Z","timestamp":1768589609456,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In 145 previously healthy non\u2010critically ill young adults, coronavirus disease 2019 (COVID\u201019)\u2010related symptoms, risk factors for thrombosis, coagulation and inflammatory parameters were compared, with 29 patients reporting unusual thrombotic events (UTEs) and 116 not having thrombotic events. The inflammatory indices, coagulation and prothrombotic platelet phenotype (PTPP) were significantly higher in patients with UTEs <jats:italic>versus<\/jats:italic> those without. Patients with UTEs were categorised according to detection of thrombophilic genes (TGs), coagulation and inflammatory markers to the non\u2010TG and TG subcohort. A total of 38 UTEs were identified, which included splanchnic vein thrombosis (SVT; 11), stroke (six), cerebral vein thrombosis (five), thrombotic microangiopathy (four), limb ischaemia and inferior vena cava thrombosis (three each), ST\u2010segment elevation myocardial infarction (two), superior vena cava thrombosis (two), upper limb deep venous thrombosis and retinal vein thrombosis, one each. We found a 55% prevalence of TGs mainly heterozygous coagulation factor II, thrombin (FII)\u2010G20210A, Janus kinase 2 (JAK2)\u2010V617F, protein\u2010S, and antithrombin III deficiency with a high (76\u00b79%) prevalence of venous UTEs, multiple vessels thrombosis, and recurrence rate among the TG <jats:italic>versus<\/jats:italic> non\u2010TG subcohort. The presence of JAK2\u2010V617F, and FII\u2010G20210A mutations was linked with SVT. Thrombosis in the non\u2010TG subcohort was associated with more haemorrhagic problems, thrombosis progression and a significantly higher level of inflammatory markers, PTPP, mean platelet volume, von Willebrand factor, and factor VIII, which remained high for up to 6\u2009months, as well as elevated D\u2010dimer. Acquired and inherited thrombophilia with endotheliopathy appeared to be a relevant mechanism to explain the occurrence of UTEs that are not correlated to COVID\u201019 severity.<\/jats:p>","DOI":"10.1111\/bjh.17986","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:26:15Z","timestamp":1639099575000},"page":"902-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Unusual pattern of thrombotic events in young adult non\u2010critically ill patients with COVID\u201019 may result from an undiagnosed inherited and acquired form of thrombophilia"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5487-9493","authenticated-orcid":false,"given":"Mahmoud I.","family":"Elbadry","sequence":"first","affiliation":[{"name":"Division of Haematology Department of Internal Medicine Faculty of Medicine Sohag University Sohag 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