{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:31:30Z","timestamp":1779384690966,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In this study, we performed a retrospective analysis of a cohort of Japanese paediatric patients with B\u2010cell precursor (BCP)\u2010acute lymphoblastic leukaemia (ALL) treated with a Berlin\u2010Frankfurt\u2010M\u00fcnster (BFM)95\u2010based protocol, to clarify the incidence, clinical characteristics, and risk factors of osteonecrosis (ON) in comparison to the ALL\u201002 protocol. We identified a high frequency of ON with the BFM95\u2010based protocol compared to the ALL\u201002 protocol. The incidence of symptomatic ON with the BFM95\u2010based protocol is comparable to previous studies in Western countries. We believe that the type of treatment regimen has more impact on the incidence of symptomatic ON in paediatric ALL than ethnicity.<\/jats:p>","DOI":"10.1111\/bjh.17988","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:11:53Z","timestamp":1639008713000},"page":"1257-1261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The incidence of symptomatic osteonecrosis is similar between Japanese children and children in Western countries with acute lymphoblastic leukaemia treated with a Berlin\u2010Frankfurt\u2010M\u00fcnster (BFM)95\u2010based protocol"],"prefix":"10.1111","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-5132","authenticated-orcid":false,"given":"Kunihiko","family":"Moriya","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tohoku University Graduate School of Medicine Sendai 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