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Conceptually, CPC\u2010defining mutations are somatic alterations shared by the initial and relapsed tumours, mostly B\u2010cell leukaemia\/lymphoma 2 (<jats:italic>BCL2<\/jats:italic>)\/immunoglobulin heavy locus (<jats:italic>IGH<\/jats:italic>) translocations and other recurrent gene mutations. Through complementary approaches for highly sensitive mutation detection, we do not find CPC\u2010defining mutations in highly purified <jats:italic>BCL2<\/jats:italic>\/<jats:italic>IGH<\/jats:italic>\u2010negative haematopoietic progenitor cells in clinical remission samples from three patients with relapsed FL. Instead, we find cells harbouring the same <jats:italic>BCL2<\/jats:italic>\/<jats:italic>IGH<\/jats:italic> translocation but lacking <jats:italic>CREB<\/jats:italic> binding protein (<jats:italic>CREBBP<\/jats:italic>), lysine methyltransferase 2D (<jats:italic>KMT2D<\/jats:italic>) and other recurrent gene mutations. Thus, (i) the <jats:italic>BCL2<\/jats:italic>\/<jats:italic>IGH<\/jats:italic> translocation can precede CPC\u2010defining mutations in human FL, and (ii) <jats:italic>BCL2<\/jats:italic>\/<jats:italic>IGH<\/jats:italic>\u2010translocated cells can persist in clinical remission.<\/jats:p>","DOI":"10.1111\/bjh.17990","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T06:19:20Z","timestamp":1640845160000},"page":"1381-1387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The molecular ontogeny of follicular lymphoma: gene mutations succeeding the <i>BCL2<\/i> translocation define common precursor cells"],"prefix":"10.1111","volume":"196","author":[{"given":"Sarah","family":"Haebe","sequence":"first","affiliation":[{"name":"Laboratory for Experimental Leukemia and Lymphoma Research (ELLF) Hospital of the Ludwig\u2010Maximilians\u2010University (LMU)  Munich 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