{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:38:51Z","timestamp":1787236731317,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["LSHB\u2010CT\u20102006\u2010018708"],"award-info":[{"award-number":["LSHB\u2010CT\u20102006\u2010018708"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The standardized EuroFlow protocol, including CD19 as primary B\u2010cell marker, enables highly sensitive and reliable minimal residual disease (MRD) assessment in B\u2010cell precursor acute lymphoblastic leukaemia (BCP\u2010ALL) patients treated with chemotherapy. We developed and validated an alternative gating strategy allowing reliable MRD analysis in BCP\u2010ALL patients treated with CD19\u2010targeting therapies. Concordant data were obtained in 92% of targeted therapy patients who remained CD19\u2010positive, whereas this was 81% in patients that became (partially) CD19\u2010negative. Nevertheless, in both groups median MRD values showed excellent correlation with the original MRD data, indicating that, despite higher interlaboratory variation, the overall MRD analysis was correct.<\/jats:p>","DOI":"10.1111\/bjh.17992","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T21:00:21Z","timestamp":1638997221000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Flow cytometric minimal residual disease assessment in B\u2010cell precursor acute lymphoblastic leukaemia patients treated with CD19\u2010targeted therapies \u2014 a EuroFlow study"],"prefix":"10.1111","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-5176","authenticated-orcid":false,"given":"Martijn W. 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