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In individual patients, circumstances may dictate an alternative approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      This guideline was compiled according to the British Society for Haematology (BSH) process at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.b-s-h.org.uk\/guidelines\/proposing-and-writing-a-new-bsh-guideline\/\">http:\/\/www.b\u2010s\u2010h.org.uk\/guidelines\/proposing\u2010and\u2010writing\u2010a\u2010new\u2010bsh\u2010guideline\/<\/jats:ext-link>\n                      . Recommendations are based on a review of the literature using Medline, Pubmed, Embase, Central, Web of Science searches from beginning of 2013 (since the publication of the previous guidelines) up to November 2021. The following search terms were used: Waldenstr\u00f6m(\u2019s) macroglobulin(a)emia OR lymphoplasmacytic lymphoma, IgM(\u2010related) neuropathy OR cold h(a)emagglutinin disease OR cold agglutinin disease OR cryoglobulin(a)emia AND (for group a only) cytogenetic OR molecular OR mutation OR MYD88 OR CXCR4, management OR treatment OR transfusion OR supportive care OR plasma exchange OR plasmapheresis OR chemotherapy OR bendamustine OR bortezomib OR ibrutinib OR fludarabine OR dexamethasone OR cyclophosphamide OR rituximab OR everolimus,\u00a0bone marrow transplantation OR stem cell transplantation. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate levels of evidence and to assess the strength of recommendations. The GRADE criteria can be found at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.gradeworkinggroup.org\">http:\/\/www.gradeworkinggroup.org<\/jats:ext-link>\n                      . Review of the manuscript was performed by the British Society for Haematology (BSH) Guidelines Committee Haemato\u2010Oncology Task Force, the BSH Guidelines Committee and the Haemato\u2010Oncology sounding board of BSH. It was also on the members section of the BSH website for comment. It has also been reviewed by UK Charity WMUK; these organisations do not necessarily approve or endorse the contents.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bjh.18036","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:49:52Z","timestamp":1641980992000},"page":"171-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Diagnosis and management of Waldenstr\u00f6m macroglobulinaemia\u2014A\n                    <i>British Society for Haematology<\/i>\n                    guideline"],"prefix":"10.1111","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6937-2852","authenticated-orcid":false,"given":"Guy","family":"Pratt","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust  Birmingham 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