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A total of 803 adults with peripheral T\u2010cell lymphoma, anaplastic large cell lymphoma and angioimmunoblastic T\u2010cell lymphoma (age 18\u201365\u00a0years), undergoing allo\u2010HCT between 2008\u20132019 and reported to the Center for International Blood and Marrow Transplant Research with either MAC (<jats:italic>n<\/jats:italic>\u00a0=\u00a0258) or RIC\/NMA regimens (<jats:italic>n<\/jats:italic>\u00a0=\u00a0545) were evaluated. There were no significant differences between the two cohorts in terms of patient sex, race and performance scores. Significantly more patients in the RIC\/NMA cohort had peripheral blood grafts, haematopoietic cell transplantation\u2010specific comorbidity index (HCT\u2010CI) of \u22653 and chemosensitive disease compared to the MAC cohort. On multivariate analysis, overall survival (OS) was not significantly different in the RIC\/NMA cohort compared to the MAC cohort (hazard ratio (HR)\u00a0=\u00a01.01, 95% confidence interval (CI)\u00a0=\u00a00.79\u20131.29; <jats:italic>p<\/jats:italic> =\u00a00.95). Similarly, non\u2010relapse mortality (NRM) (HR\u00a0=\u00a00.85, 95% CI\u00a0=\u00a00.61\u20131.19; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.34), risk of progression\/relapse (HR\u00a0=\u00a01.29; 95% CI\u00a0=\u00a00.98\u20131.70; <jats:italic>p<\/jats:italic> =\u00a00.07) and therapy failure (HR\u00a0=\u00a01.14; 95% CI\u00a0=\u00a00.92\u20131.41, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.23) were not significantly different between the two cohorts. Relative to MAC, RIC\/NMA was associated with a significantly lower risk of grade 3\u20134 acute graft\u2010versus\u2010host disease (HR\u00a0=\u00a00.67; 95% CI\u00a0=\u00a00.46\u20130.99, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Among chemorefractory patients, there was no difference in OS, therapy failure, relapse, or NRM between RIC\/NMA and MAC regimens. In conclusion, we found no association between conditioning intensity and outcomes after allo\u2010HCT for T\u2010cell NHL.<\/jats:p>","DOI":"10.1111\/bjh.18052","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T09:58:35Z","timestamp":1643795915000},"page":"212-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Impact of conditioning regimen intensity on the outcomes of peripheral T\u2010cell lymphoma, anaplastic large cell lymphoma and angioimmunoblastic T\u2010cell lymphoma patients undergoing allogeneic transplant"],"prefix":"10.1111","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-1389","authenticated-orcid":false,"given":"Malvi","family":"Savani","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine University of Arizona and University of Arizona Cancer Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang W.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Institute for Health and Equity Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Department of Medicine, Center for International Blood and Marrow Transplant Research Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for International Blood and Marrow Transplant Research Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-8299","authenticated-orcid":false,"given":"Sairah","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Cancer Medicine, Departments of Lymphoma\/Myeloma and Stem Cell Transplantation University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda\u00a0F.","family":"Cashen","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine Washington University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazyar","family":"Shadman","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington, Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-8844","authenticated-orcid":false,"given":"Dipenkumar","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute, Wayne State University  Detroit Michigan USA"},{"name":"Division of Hematology\u2010Oncology Karmanos Cancer Institute, Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Khimani","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplant and Cellular Immunotherapy H. 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