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This large population\u2010based longitudinal study therefore investigated the long\u2010term HRQoL and persistence of symptoms and identified associated sociodemographic, clinical and psychological factors. Patients diagnosed between 1999 and 2014 and four or more months after diagnosis were invited to participate in a longitudinal survey. Sociodemographic and clinical data were obtained from the Netherlands Cancer Registry. The EORTC QLQ\u2010C30 and CLL\u201016 were completed by 669 patients (74% response rate). Patients completed on average four questionnaires. Primary treatment was active surveillance (52%), systemic therapy (31%) or radiotherapy (13%). Respectively, 36% reported persistent fatigue, 33% persistent neuropathy and 25% persistent role\u2010functioning impairment. This was 2\u20133 times higher than in the age\u2010 and sex\u2010matched normative population. Up to 10\u00a0years after diagnosis, scores remained relatively stable without clinically relevant changes. Comorbidities, psychological distress, shorter time since diagnosis, systemic therapy, younger age, education level and having no partner were associated with worse outcomes (all <jats:italic>p<\/jats:italic>s\u00a0&lt;\u00a00.05). Up to a third of patients with iNHL experience long\u2010term persistent symptoms which do not improve over time. Early recognition of symptoms will help in providing tailored supportive care for those in need.<\/jats:p>","DOI":"10.1111\/bjh.18139","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T08:58:24Z","timestamp":1648889904000},"page":"590-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Persistent symptoms of fatigue, neuropathy and role\u2010functioning impairment among indolent <scp>non\u2010Hodgkin<\/scp> lymphoma survivors: A\u00a0longitudinal <scp>PROFILES<\/scp> registry study"],"prefix":"10.1111","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6262-8213","authenticated-orcid":false,"given":"Afke","family":"Ekels","sequence":"first","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organization (IKNL)  Utrecht The Netherlands"},{"name":"Division of Psychosocial Research and Epidemiology Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonneke V.","family":"van de Poll\u2010Franse","sequence":"additional","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organization (IKNL)  Utrecht The Netherlands"},{"name":"Division of Psychosocial Research and Epidemiology Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Department of Medical and Clinical Psychology Center of Research on Psychological and Somatic Disorders (CoRPS), Tilburg University  Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardus F. 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