{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:05:26Z","timestamp":1790949926922,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Waldenstr\u00f6m's macroglobulinaemia (WM) is a B\u2010cell neoplasm resulting from bone marrow lymphoplasmacytic infiltration and monoclonal IgM secretion. Some patients present concomitant inflammatory syndrome attributed to the disease activity; we named this syndrome inflammatory WM (IWM). We retrospectively analysed all WM patients seen in a single tertiary referral centre from January 2007 to May 2021, and after excluding aetiologies for the inflammatory syndrome using a pertinent blood workup, including C\u2010reactive protein (CRP), and imaging, we identified 67 (28%) IWM, 166 (68%) non\u2010IWM, and nine (4%) WM with inflammatory syndrome of unknown origin. At treatment initiation, IWM patients had more severe anaemia (median Hb 90 vs 99\u00a0g\/l; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), higher platelet count (median 245 vs 196\u00a0\u00d7\u00a0109\/l; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and comparable serum IgM level (median 24.9 vs 23.0\u00a0g\/l; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.28). A positive correlation was found between inflammatory and haematological responses (minimal response or better) (odds ratio 32.08; 95% confidence interval 8.80\u201398.03; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Overall survivals (OS) were similar (median OS: 17 vs 20\u00a0years; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.11) but time to next treatment (TNT) was significantly shorter for IWM (TNT1: 1.6 vs 4.8\u00a0years, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). IWM mostly shared the same presentation and outcome as WM without inflammatory syndrome.<\/jats:p>","DOI":"10.1111\/bjh.18157","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T08:43:58Z","timestamp":1649407438000},"page":"728-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inflammatory Waldenstr\u00f6m's macroglobulinaemia: A French monocentric retrospective study of 67 patients"],"prefix":"10.1111","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-4611","authenticated-orcid":false,"given":"Dikelele","family":"Elessa","sequence":"first","affiliation":[{"name":"Department of Immuno Haematology Hopital Saint\u2010Louis, Assistance Publique H\u00f4pitaux de Paris  Paris France"},{"name":"University of Paris  Paris 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