{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:45:55Z","timestamp":1747183555826,"version":"3.40.5"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["OMB114361"],"award-info":[{"award-number":["OMB114361"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The efficacy of salvage treatment of diffuse large B\u2010cell lymphoma (DLBCL) patients who relapse or progress (rrDLBCL) after initial therapy is limited. Efficacy and safety of ofatumumab with iphosphamide, etoposide and cytarabine (O\u2010IVAC) was evaluated in a single\u2010arm study. Dosing was modified for elderly patients. Patients received up to six cycles of treatment. The primary end\u2010point was the overall response rate (ORR). Patients were evaluated every two cycles and then six and 12\u00a0months after treatment. Other end\u2010points included progression\u2010free survival (PFS), event\u2010free survival (EFS), overall survival (OS) and safety. Seventy\u2010seven patients received salvage treatment with O\u2010IVAC. The average age was 56.8\u00a0years; 39% had an Eastern Cooperative Oncology Group (ECOG) performance status of at least 3; 78% had disease of Ann Arbor stage 3 or 4; 58% received one or more prior salvage therapies. The ORR for O\u2010IVAC was 54.5%. The median duration of study follow\u2010up was 70\u00a0months. The median PFS and EFS were 16.3\u00a0months each. The median OS was 22.7\u00a0months. Age, ECOG performance status and the number of prior therapy lines were independent predictors of survival. Treatment\u2010related mortality was 15.5%. O\u2010IVAC showed a high response rate in a difficult\u2010to\u2010treat population and is an attractive treatment to bridge to potentially curative therapies.<\/jats:p>","DOI":"10.1111\/bjh.18166","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T09:04:58Z","timestamp":1648803898000},"page":"73-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ofatumumab with iphosphamide, etoposide and cytarabine for patients with transplantation\u2010ineligible relapsed and refractory diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-3932","authenticated-orcid":false,"given":"Ewa","family":"Paszkiewicz\u2010Kozik","sequence":"first","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Michalski","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Taszner","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk  Gdansk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Mordak\u2010Domaga\u0142a","sequence":"additional","affiliation":[{"name":"Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-1112","authenticated-orcid":false,"given":"Joanna","family":"Romejko\u2010Jarosi\u0144ska","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda","family":"Knopi\u0144ska\u2010Pos\u0142uszny","sequence":"additional","affiliation":[{"name":"Maritime Hospital  Gdynia Poland"},{"name":"Warmian\u2010Masurian Cancer Center of the Ministry of the Interior and Administration's Hospital  Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Najda","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Borawska","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Che\u0142stowska","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"\u015awierkowska","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"D\u0105browska\u2010Iwanicka","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Malenda","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Druzd\u2010Sitek","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Konecki","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Kumiega","sequence":"additional","affiliation":[{"name":"Sniadecki Memorial Specialist Hospital  Nowy Sacz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Osowiecki","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Ostrowska","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Szpila","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Szyma\u0144ski","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Targo\u0144ski","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Doma\u0144ska\u2010Czy\u017c","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Pop\u0142awska","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Giebel","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Lange","sequence":"additional","affiliation":[{"name":"Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Pluta","sequence":"additional","affiliation":[{"name":"Department of Hematology Brzozow Oncology Center  Brzozow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Maciej","family":"Zaucha","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk  Gdansk Poland"},{"name":"Maritime Hospital  Gdynia Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Rymkiewicz","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Walewski","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70235-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276246"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.131"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.1618"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.9593"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.06.036"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15412"},{"key":"e_1_2_9_10_1","unstructured":"National Comprehensive Cancer Network.B\u2010Cell Lymphomas. National Comprehensive Cancer Network;202122\/09\/2021."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.213"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-769620"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2019-0062"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707447"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01756-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26301"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00172"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1795154"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30225-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00139-X"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30120-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0056"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-111781"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.3187"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(16)30171-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.0198"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12537"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.11.005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0286"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117671"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf253"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.05.016"},{"issue":"12","key":"e_1_2_9_34_1","first-page":"1366","article-title":"A pilot study of CODOX\u2010M\/IVAC in primary refractory or relapsed high\u2010grade non\u2010Hodgkin's lymphoma. A Scotland and Newcastle Lymphoma Group Study","volume":"88","author":"Davidson KL","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-145128"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.110_2631"},{"key":"e_1_2_9_37_1","unstructured":"JaffeE SwerdlowSHCE CampoE PileriS ThieleJ HarrisN et al. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues 2008."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_9_40_1","first-page":"641","article-title":"Common Terminology Criteria for Adverse Events (CTCAE) version 4.03. Internet: US Department of health and human services","volume":"2","author":"National Cancer Institute","year":"2010","journal-title":"National Institutes of Health"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90015-9"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.08.015"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11613"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13440"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903503404"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.n.017"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600926572"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.090597"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16255"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1564828"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31981"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30864-7"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31366-0"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T06:28:43Z","timestamp":1693463323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/bjh.18166"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18166","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"2022-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}