{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:32:23Z","timestamp":1788345143283,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Most cases of fetal and neonatal thrombocytopenia (FNAIT) are caused by maternal anti\u2010human platelet antigen\u20101a antibodies (anti\u2010HPA\u20101a). Anti\u2010HPA\u20105b antibodies are the second most common antibodies in suspected FNAIT cases. Given the high prevalence of anti\u2010HPA\u20105b antibodies in pregnant women delivering healthy newborns, the association with FNAIT may be coincidental. This review of the literature related to FNAIT using the MEDLINE database was conducted according to PRISMA guidelines. A retrospective analysis of a single\u2010centre cohort of 817 suspected FNAIT cases was conducted. The pooled prevalence of anti\u2010HPA\u20105b antibodies in unselected pregnant women of European descent was 1.96% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03113), compared with 3.4% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05003) in women with suspected FNAIT. We found weak evidence that a small proportion of pregnant women presenting with anti\u2010HPA\u20105b antibodies will give birth to a newborn with mild thrombocytopenia. The neonatal platelet counts were not different between suspected FNAIT cases (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0817) with and without maternal anti\u2010HPA\u20105b antibodies. The prevalence of maternal anti\u2010HPA\u20105b antibodies was not different between neonates with intracranial haemorrhage and healthy controls. The current experimental and epidemiological evidence does not support the hypothesis that anti\u2010HPA\u20105b antibodies cause severe thrombocytopenia or bleeding complications in the fetus or newborn.\n                  <\/jats:p>","DOI":"10.1111\/bjh.18173","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T08:24:53Z","timestamp":1649147093000},"page":"14-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anti\u2010human platelet antigen\u20105b antibodies and fetal and neonatal alloimmune thrombocytopenia; incidental association or cause and effect?"],"prefix":"10.1111","volume":"198","author":[{"given":"Julia","family":"Alm","sequence":"first","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine Justus\u2010Liebig\u2010University  Giessen 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