{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:49:30Z","timestamp":1790020170384,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Several recently published trials investigate novel therapies for relapsed\/refractory diffuse large B\u2010cell lymphoma (R\/R DLBCL). To estimate the benefit of these therapies in the real\u2010world setting, comprehensive data on patients treated in clinical routine are needed. We report outcomes for 736 R\/R DLBCL patients identified among all curatively treated DLBCL patients in Sweden in the period 2007\u20132014. Survival and associations with disease characteristics, second\u2010line treatment and fulfilment of chimaeric antigen receptor (CAR) T\u2010cell trial criteria were assessed. Median overall survival (OS) was 6.6\u2009months (\u226470\u2009years 9.6\u2009months, &gt;70\u2009years 4.9\u2009months). Early relapse (\u226412\u00a0months) was strongly associated with selection of less intensive treatment and poor survival. Among patients of at most 70\u2009years of age, 63% started intensive second\u2010line treatment and 34% received autologous stem cell transplantation (ASCT). Two\u2010year OS among transplanted patients was 56% (early relapse \u226412\u2009months 40%, late relapse &gt;12\u2009months 66%). A minority of patients 76\u2009years (<jats:italic>n<\/jats:italic>\u00a0=\u2009178\/506, 35%) fitted CAR T trial criteria. Median progression\u2010free survival (PFS) for patients with early relapse fitting trial criteria was 4.8\u2009months. In conclusion, most R\/R DLBCL manifest early and are often ineligible for or cannot complete intensive regimens resulting in dismal survival. Real\u2010world patients eligible for CAR T trials also did poorly, providing a benchmark for efficacy of novel therapies.<\/jats:p>","DOI":"10.1111\/bjh.18197","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T16:04:41Z","timestamp":1650902681000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Outcomes of relapsed\/refractory diffuse large B\u2010cell lymphoma and influence of chimaeric antigen receptor T trial eligibility criteria in second line\u2014A population\u2010based study of 736 patients"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-4728","authenticated-orcid":false,"given":"Sara","family":"Harrysson","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University 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C.","family":"El\u2010Galaly","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-1340","authenticated-orcid":false,"given":"Birgitta","family":"Sander","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Laboratory Medicine Karolinska Institutet and Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7306-2371","authenticated-orcid":false,"given":"Kristina","family":"Sonnevi","sequence":"additional","affiliation":[{"name":"Department of Hematology Karolinska University Hospital  Solna 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