{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:46:22Z","timestamp":1760028382813,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. 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Trial\u2010level surrogacy examining the association between treatment effects on EoI\u2010PET\u2010CR and PFS was evaluated using linear regression () and bivariate Copula () models. Although EoI\u2010PET\u2010CR strongly predicted PFS at a prognostic level, the trial\u2010level assessment did not show strong correlation (, confidence interval [CI]: 0.20\u20130.88; , CI: 0.0\u20130.82). The high uncertainty in estimation was possibly due to the small number of trials and the population of patients with available PET data. Maintenance therapy affecting PFS beyond induction treatment, but not EoI\u2010PET\u2010CR end\u2010point, may have distorted the association between treatment effects. However, there will probably be a number of additional trials approaching completion with available PET response data. Refined evaluation of PET\u2010CR based surrogate end\u2010points is still warranted.<\/jats:p>","DOI":"10.1111\/bjh.18217","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T07:59:38Z","timestamp":1651478378000},"page":"333-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["End of induction positron emission tomography complete response (PET\u2010CR) as a surrogate for progression\u2010free survival in previously untreated follicular lymphoma"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-1564","authenticated-orcid":false,"given":"Jesse G.","family":"Dixon","sequence":"first","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Dimier","sequence":"additional","affiliation":[{"name":"Biostatistics Roche Products Ltd  Welwyn Garden City UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Biostatistics Roche Products Ltd  Welwyn Garden City UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Worldwide Medical Affairs Hematology\/Lymphoma\/CLL Bristol\u2010Myers Squibb  Plainsboro New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Marcus","sequence":"additional","affiliation":[{"name":"Department of Haematology King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Morschhauser","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les formes Injectables et les Technologies Associees University of Lille, CHU Lille  Lille 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