{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:39:00Z","timestamp":1791517140840,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hodgkin variant Richter transformation (HvRT) is a rare and challenging complication of chronic lymphocytic leukaemia (CLL) for which information on prognostic factors and treatment approaches remain limited. We analysed characteristics and survival outcomes of a population\u2010based cohort of 32 patients with HvRT identified in British Columbia over a 40\u2010year period. Median interval from CLL diagnosis to HvRT was 5.6\u2009years (range, 0\u201333.6), with five cases diagnosed concurrently. Most patients (80%) had treatment for CLL prior to HvRT. Median age at HvRT was 71\u2009years (range, 51\u201386) and the majority of patients had high\u2010risk disease, including stage 3\u20134 in 87% and International Prognostic Score (IPS)\u2009\u2265\u20094 in 65%. Two\u2010year progression\u2010free (PFS) and overall survival (OS) from HvRT were 47% (95% CI: 29%\u201364%) and 57% (95% CI: 38%\u201372%), respectively. OS from HvRT was significantly worse in those with anaemia (<jats:italic>p<\/jats:italic>\u00a0=\u20090.02), elevated lactate dehydrogenase (<jats:italic>p<\/jats:italic>\u00a0=\u20090.04), high IPS (<jats:italic>p<\/jats:italic>\u00a0=\u20090.04), and worse performance status (<jats:italic>p<\/jats:italic>\u00a0=\u20090.001). For those treated with curative\u2010intent ABVD\/ABVD\u2010like therapy, 2\u2010year PFS and OS were 70% (95% CI: 45%\u201385%) and 74% (95% CI: 49%\u201389%), respectively. In this real\u2010world population\u2010based cohort, HvRT was associated with poor clinical outcomes overall; however, those able to tolerate curative\u2010intent therapy had similar survival to older patients with <jats:italic>de novo<\/jats:italic> HL.<\/jats:p>","DOI":"10.1111\/bjh.18241","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T09:43:54Z","timestamp":1652521434000},"page":"684-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Outcomes of Hodgkin variant Richter transformation in chronic lymphocytic leukaemia and small lymphocytic lymphoma in British Columbia"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-5486","authenticated-orcid":false,"given":"Kai","family":"Zhu","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jamroz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Faculty of Medicine Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Huang","sequence":"additional","affiliation":[{"name":"Leukemia\/Bone Marrow Transplant Program of BC and Division of Hematology BC Cancer, University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-3009","authenticated-orcid":false,"given":"Diego","family":"Villa","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer and Division of Medical Oncology BC Cancer, University of British Columbia  Vancouver British Columbia 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