{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:59:26Z","timestamp":1771592366014,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004486","name":"Fondazione Cassa di Risparmio di Perugia","doi-asserted-by":"publisher","award":["Project 19663 (2020.0508)"],"award-info":[{"award-number":["Project 19663 (2020.0508)"]}],"id":[{"id":"10.13039\/501100004486","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To slow down the coronavirus disease 2019 (COVID\u201019) pandemic an unequalled vaccination campaign was initiated. Despite proven efficacy and safety, a rare but potentially fatal complication of adenoviral\u2010vector vaccines, called vaccine\u2010induced immune thrombotic thrombocytopenia (VITT), has emerged the pathogenesis of which seems to be related to the development of platelet\u2010activating anti\u2010platelet factor 4 (PF4) antibodies. While a few studies have evaluated the incidence of anti\u2010PF4 positivity in anti\u2010severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) vaccine recipients, to date no studies have assessed whether an antiplatelet immunological response develops and if this associates with platelet and blood clotting activation. We carried out a prospective study in healthy subjects who received the first dose of ChAdOx1 or Ad26.COV2.S or BNT162b2 vaccines to evaluate platelet\u2010specific and non\u2010specific immune response and in vivo platelet activation and blood clotting activation. Individuals receiving ChAdOx1 and, less so, Ad26.COV2.S developed with high frequency auto\u2010 or alloantiplatelet antibodies, increased circulating platelet\u2010derived microvesicles and soluble P\u2010selectin associated with mild blood clotting activation. Our study shows that an immunological reaction involving platelets is not uncommon in individuals receiving anti\u2010SARS\u2010CoV\u20102 vaccination, especially after ChAdOx1 and Ad26.COV2.S, and that it associates with in vivo platelet and blood clotting activation.<\/jats:p>","DOI":"10.1111\/bjh.18245","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T01:12:05Z","timestamp":1652749925000},"page":"257-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<scp>Anti\u2010severe acute respiratory syndrome coronavirus\u20102<\/scp> adenoviral\u2010vector vaccines trigger subclinical antiplatelet autoimmunity and increase of soluble platelet activation markers"],"prefix":"10.1111","volume":"198","author":[{"given":"Eleonora","family":"Petito","sequence":"first","affiliation":[{"name":"Section of Internal and Cardiovascular Medicine University of Perugia  Perugia 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