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neurodegeneration in the central nervous system (ND\u2010CNS\u2010LCH). Neurofilament light protein (NFL) in cerebrospinal fluid (CSF) is a promising biomarker to detect and monitor ND\u2010CNS\u2010LCH. We compared paired samples of NFL in plasma (p\u2010NFL) and CSF in 10 patients (19 samples). Nine samples had abnormal CSF\u2010NFL (defined as \u2265380\u2009ng\/l) with corresponding p\u2010NFL\u2009\u2265\u20092\u00a0ng\/l. Ten samples had CSF\u2010NFL\u2009&lt;\u2009380\u2009ng\/l; eight (80%) with p\u2010NFL\u2009&lt;\u20092\u00a0ng\/l (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; Fisher's exact test). Thus, our results suggest that p\u2010NFL may be used to screen for ND\u2010CNS\u2010LCH. 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