{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:29:04Z","timestamp":1787812144159,"version":"build-2784847793"},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immune thrombocytopenia (ITP) may cause menstrual problems. This cross\u2010sectional study assessed menstrual problems in premenopausal chronic ITP women by several questionnaires, including the pictorial bleeding assessment calendar (PBAC; score\u2009\u2265100 indicates heavy menstrual bleeding [HMB]), and the menorrhagia multiattribute scale (MMAS). Spearman was used for assessing correlations. A literature review was performed in Pubmed. The cohort comprised 37 women (mean age 31\u2009\u00b1\u20099). A total of 29\/37 (78%) had experienced clinical menstrual problems in the present or past. Of the 33 patients who returned the PBAC, 13 (39%) had a score of \u2265100. The median MMAS score was 79 (IQR 60\u201395). The PBAC scores correlated with the MMAS. Both questionnaires were unrelated to the platelet count. Patients with a levonorgestrel intrauterine device (LNG\u2010IUD) had lower PBAC scores than patients with other or no hormonal therapy. MMAS scores were correlated with fatigue. The review identified 14 papers. HMB occurred in 6%\u201355% at ITP diagnosis and 17%\u201379% during disease. Menstrual symptoms influenced the quality of life, particularly in patients with a low platelet count. This explorative study suggested that HMB is frequent in women with chronic ITP despite management and platelet counts &gt;50 *10<jats:sup>9<\/jats:sup>\/l. An LNG\u2010IUD seemed to reduce blood loss significantly.<\/jats:p>","DOI":"10.1111\/bjh.18291","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T06:13:49Z","timestamp":1654323229000},"page":"753-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Menstrual problems in chronic immune thrombocytopenia: A\u00a0monthly challenge \u2010 a cohort study and review"],"prefix":"10.1111","volume":"198","author":[{"given":"Wobke E. 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