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We investigated the effect of cytoreductive treatment on platelet function and turnover in ET patients. Blood samples were obtained at 1 and 24\u2009h after aspirin intake. Platelet function was evaluated by platelet aggregation and flow cytometry. Platelet turnover was assessed by immature platelet count, immature platelet fraction (IPF) and mean platelet volume (MPV). A total of 47 ET patients were included and grouped into 21 patients not receiving cytoreductive treatment, 15 patients receiving hydroxycarbamide and 11 patients receiving pegylated interferon alpha (peg\u2010IFN). Patients receiving peg\u2010IFN had significantly higher IPF and MPV than the other ET groups. Patients not receiving cytoreductive treatment had significantly higher platelet aggregation 24\u2009h after aspirin intake than the other ET groups (<jats:italic>p<\/jats:italic>\u2010values from 0.03 to 0.0002). Patients receiving hydroxycarbamide had significantly higher expression of platelet granule makers, P\u2010selectin and CD63, than patients receiving peg\u2010IFN (<jats:italic>p<\/jats:italic>\u2010values \u22640.003). Cytoreduction provides more consistent platelet inhibition compared with no cytoreductive treatment. Moreover, peg\u2010IFN provides superior inhibition of platelet activation markers than hydroxycarbamide, which in part may explain differences in risk of thromboembolic events in ET patients.<\/jats:p>","DOI":"10.1111\/bjh.18303","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:47:44Z","timestamp":1654735664000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytoreductive treatment and association with platelet function and maturity in patients with essential thrombocythaemia"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-270X","authenticated-orcid":false,"given":"Oliver Buchhave","family":"Pedersen","sequence":"first","affiliation":[{"name":"Thrombosis and Haemostasis Research Unit, Department of Clinical Biochemistry Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik Lerkevang","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Pasalic","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pathology and Medical Research and the Departments of Clinical and Laboratory Haematology Westmead Hospital  Sydney Australia"},{"name":"Westmead Clinical School, Faculty of Medicine and Health University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Beier","family":"Ommen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen Dalby","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Research Unit, Department of Clinical Biochemistry Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.09.017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.08.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043800"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004596"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1430356"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-359224"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731309"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01020-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321704"},{"key":"e_1_2_8_12_1","unstructured":"SwerdlowSH CampoE HarrisNL JaffeES PileriSA SteinH et al.WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 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