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Concerns about blood safety due to the high risk of bloodborne infections in sub\u2010Saharan Africa limits the application of this cost\u2010effective strategy in the management of individuals with SCD. In a single\u2010centre, retrospective, longitudinal study in southwest Nigeria, we hypothesised that the use of stringent blood donor selection, along with very sensitive enzyme\u2010linked immunosorbent assay (ELISA) screening methods would reduce transfusion\u2010transmitted infections (TTIs). Among 45\u2009002 eligible blood donors at the Lagos University Teaching Hospital in Nigeria, over a 5\u2010year review period (2015\u20132019), the seroprevalence rate of viral TTIs was 9.83%. The seroprevalence rates for human immunodeficiency, hepatitis B, and hepatitis C viruses were 1.37%, 6.2%, and 2.25% respectively. Among 172 children with SCD, 71% (122\/172) on regular blood transfusion and 29% (50\/172) who had never been transfused or had less than two transfusions per lifetime, none acquired any TTIs using our enhanced screening approach during the study period. Thus, safe blood transfusion practices can be provided for children with SCD in sub\u2010Saharan Africa with the use of stringent donor selection protocols and fourth\u2010generation ELISA kits for TTI screening.<\/jats:p>","DOI":"10.1111\/bjh.18313","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T05:40:02Z","timestamp":1655703602000},"page":"745-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reduction in seroprevalence of viral transfusion\u2010transmitted infections in southwest Nigeria in children with sickle cell disease using an enhanced screening strategy"],"prefix":"10.1111","volume":"198","author":[{"given":"Ann A.","family":"Ogbenna","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Transfusion College of Medicine\/Lagos University Teaching Hospital  Lagos 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