{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:36Z","timestamp":1787013936036,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Invasive fungal disease (IFD) remains a challenging complication of treatment for paediatric acute leukaemia. Consensus fungal treatment guidelines recommend withholding chemotherapy to facilitate immune recovery in this setting, yet prolonged delays in leukaemia therapy increase risk of relapse. Blinatumomab, a bispecific T\u2010cell engager targeting cells expressing CD19, has shown promise for treatment of relapsed\/refractory B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL) and is associated with reduced toxicity compared to conventional chemotherapy. With close monitoring of minimal residual disease, we demonstrate that children with B\u2010ALL can receive repeated cycles of bridging blinatumomab whilst conventional chemotherapy is withheld during treatment and recovery from IFD.<\/jats:p>","DOI":"10.1111\/bjh.18314","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T14:14:56Z","timestamp":1655820896000},"page":"887-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Blinatumomab as bridging therapy in paediatric B\u2010cell acute lymphoblastic leukaemia complicated by invasive fungal disease"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-612X","authenticated-orcid":false,"given":"Daniel K.","family":"Yeoh","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Sir Peter MacCallum 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