{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:34:04Z","timestamp":1788240844055,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Therapeutic management of patients with immune thrombocytopenia (ITP) remains challenging; however, thrombopoietin receptor agonists (TPO\u2010RAs) have revolutionised the treatment landscape of ITP. It is increasingly hypothesised that TPO\u2010RAs may have an immune modulatory role and Pizzi and colleagues provide evidence in support of this by demonstrating that TPO\u2010RA treatment restores the decreased regulatory T cell (Treg) numbers in the splenic microenvironment of patients with ITP.<\/jats:p><jats:p>Commentary on: Pizzi M, Vianello F, Binotto G, Vianelli N, Carli G, Auteri G, et al. Thrombopoietin receptor agonists increase splenic regulatory T\u2010cell numbers in Immune Thrombocytopenia. Br J Haematol. 2022;198:916\u2013922.<\/jats:p>","DOI":"10.1111\/bjh.18332","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T08:54:37Z","timestamp":1656060877000},"page":"803-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regulatory T cells are replenished in the splenic microenvironment of patients with immune thrombocytopenia by treatment with thrombopoietin receptor agonists"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-876X","authenticated-orcid":false,"given":"Rick","family":"Kapur","sequence":"first","affiliation":[{"name":"Sanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6020016"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003599"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153403"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000612"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.04.010"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1624709"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-432575"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010097"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281717"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16459"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18309"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2016.07.004"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18332","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T11:01:57Z","timestamp":1692356517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/bjh.18332"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18332","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]},"assertion":[{"value":"2022-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}