{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:19:41Z","timestamp":1789438781732,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The objective of the study was to compare the maternal and foetal outcomes of pregnancies complicated by Hb H\u2010constant spring (HbH\u2010CS) disease\/deletional HbH (HbH\u2010del) disease and low\u2010risk pregnancies. A retrospective cohort research was undertaken on singleton pregnancies with Hb H\u2010CS and Hb H\u2010del diseases. The controls were randomly selected with a control\u2010to\u2010case ratio of 10:1. A total of 55 cases of HbH\u2010CS disease, 231 cases of HbH\u2010del disease and 2860 controls were compared. The mean gestational age at delivery and birthweight were significantly lower in the HbH\u2010CS group than in the HbH\u2010del and control groups. The clinical course of Hb H\u2010CS was more severe than that of HbH\u2010del disease. The rates of preterm birth, foetal growth restriction and low birthweight were significantly increased in the HbH\u2010CS and Hb H\u2010del groups. These rates were significantly greater in the HbH\u2010CS group than in the H\u2010del group. The maternal outcomes were not significantly different among the three groups. In conclusion, pregnancy worsens the course of HbH disease, more noticeably in HbH\u2010CS disease. Hb H disease significantly increases the risk of adverse foetal outcomes, more noticeably in the HbH\u2010CS group. Pregnancy is relatively safe for women with HbH disease.<\/jats:p>","DOI":"10.1111\/bjh.18338","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T13:29:00Z","timestamp":1656595740000},"page":"122-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Outcomes of pregnancies complicated by haemoglobin\n                    <scp>H\u2010constant<\/scp>\n                    spring and deletional haemoglobin H disease: A retrospective cohort study"],"prefix":"10.1111","volume":"199","author":[{"given":"Srimeunwai","family":"Ake\u2010sittipaisarn","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supatra","family":"Sirichotiyakul","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasemsri","family":"Srisupundit","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchaya","family":"Luewan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-2128","authenticated-orcid":false,"given":"Kuntharee","family":"Traisrisilp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai 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