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Since few data are available regarding hypercalciuria in \u03b2\u2010thalassaemia major (TM), the aim of our study was to evaluate its prevalence, risk factors and clinical consequences. We enrolled 176 adult TM patients followed at the Center of Thalassemia of Ferrara. Hypercalciuria was defined by a calciuria of 4\u00a0mg\/kg\/day or more in a 24\u2010h urine sample. Anamnestic, biochemical and radiological data were collected. Hypercalciuria prevalence was reported in 69.3% of patients (females 52.5%). Hypercalciuric (HC) patients used deferasirox (DFX) more often than normocalciuric (NC) patients (47.5% vs 29.6%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In HC subjects plasma parathyroid hormone (PTH) (24.1\u2009\u00b1\u200910.4 vs 30.1\u2009\u00b1\u200913.2\u00a0pg\/ml) and phosphate levels (3.6\u2009\u00b1\u20090.5 vs 3.8\u2009\u00b1\u20090.7\u00a0mg\/dl) were lower, whereas serum calcium (9.6\u2009\u00b1\u20090.4 vs 9.4\u2009\u00b1\u20090.4\u00a0mg\/dl) and urinary 24\u2010h phosphaturia (0.9\u2009\u00b1\u20090.4 vs 0.6\u2009\u00b1\u20090.3\u00a0g\/day) were higher as compared to NC patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for all comparisons). Supplementation with oral calcium and cholecalciferol was similar between the groups. A higher rate of kidney stones was present in HC (14.8%) versus NC patients (3.7%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Hypercalciuria is a frequent complication in adequately treated adult TM patients. Hypercalciuria prevalence is increased in DFX users whereas haemoglobin level or calcium supplements play no role. A significant proportion of HC patients developed kidney stones.<\/jats:p>","DOI":"10.1111\/bjh.18345","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T03:53:12Z","timestamp":1656561192000},"page":"903-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Beta\u2010thalassaemia major: Prevalence, risk factors and clinical consequences of hypercalciuria"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-8593","authenticated-orcid":false,"given":"Ludovica","family":"Aliberti","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology and Internal Medicine University of Ferrara  Ferrara 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