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In this phase II study (2016\u20132021), 81 adult patients with advanced\u2010stage DLBCL (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a053) and c\u2010HL (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a028) received front\u2010line treatment with R\u2010COMP\u2010dose\u2010intensified (DI) and MBVD\u2010DI. R\u2010COMP\u2010DI consisted of 70\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    of NPLD plus standard rituximab, cyclophosphamide, vincristine and prednisone for three cycles (followed by three cycles with NPLD de\u2010escalated at 50\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ); MBVD\u2010DI consisted of 35\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    of NPLD plus standard bleomycin, vinblastine and dacarbazine for two cycles (followed by four cycles with NPLD de\u2010escalated at 25\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ). Patients underwent R\u2010COMP\u2010DI and MBVD\u2010DI with a median dose intensity of 91% and 94% respectively. At interim\u2010FDG\u2010PET, 72\/81 patients (one failed to undergo interim\u2010FDG\u2010PET due to early death) had a Deauville score of \u22643. At end of treatment, 90% of patients reached complete responses. In all, 20 patients had Grade \u22653 adverse events, and four of them required hospitalisation. At a median 21\u2010months of follow\u2010up, the progression\u2010free survival of the entire population was 77.3% (95% confidence interval 68%\u201388%). Our data suggest that the NPLD supercharge\u2010driven strategy in high\u2010risk DLBCL\/c\u2010HL may be a promising option to test in phase III trials, for improving negative interim\u2010FDG\u2010PET cases incidence.\n                  <\/jats:p>","DOI":"10.1111\/bjh.18348","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T12:55:00Z","timestamp":1657630500000},"page":"847-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Liposomal doxorubicin supercharge\u2010containing front\u2010line treatment in patients with advanced\u2010stage diffuse large B\u2010cell lymphoma or classical Hodgkin lymphoma: Preliminary results of a single\u2010centre phase II study"],"prefix":"10.1111","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-2524","authenticated-orcid":false,"given":"Marco","family":"Picardi","sequence":"first","affiliation":[{"name":"Department of 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